{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T11:36:41Z","timestamp":1790941001428,"version":"4.1.0"},"reference-count":20,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2007,2,5]],"date-time":"2007-02-05T00:00:00Z","timestamp":1170633600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2007,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To extend observations on intra\u2010renal oxygenation with blood oxygen level\u2010dependent (BOLD) MRI in human and rats to mouse kidneys imaged with a human whole\u2010body scanner.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Renal BOLD MRI studies were performed on a 3.0T scanner using a multiple gradient\u2010echo (mGRE) sequence with a custom\u2010designed 2.0\u2010cm surface coil to acquire six T<jats:sub>2<\/jats:sub>*\u2010weighted images in mice (<jats:italic>N<\/jats:italic> = 8) at an in\u2010plane resolution of 156 \u00d7 156 \u03bcm<jats:sup>2<\/jats:sup>. BOLD MRI data were obtained before and after administration of furosemide (10 mg\/kg intravenously [i.v.]).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean weight of eight mice was 24.6 \u00b1 1.0 g. The baseline renal R<jats:sub>2<\/jats:sub>* (mean \u00b1 standard error [SE]) was 28.6 \u00b1 2.1 seconds<jats:sup>\u20131<\/jats:sup> in the renal cortex (CO), 35.4 \u00b1 2.2 in the outer medulla (OM), and 21.2 \u00b1 2.1 seconds<jats:sup>\u20131<\/jats:sup> in the inner medulla (IM). The BOLD response to furosemide (\u0394R<jats:sub>2<\/jats:sub>*) was 4.1 \u00b1 1.4 in the CO, 10.1 \u00b1 2.1 seconds<jats:sup>\u20131<\/jats:sup> in the OM, and 3.4 \u00b1 0.8 seconds<jats:sup>\u20131<\/jats:sup> in the IM in mice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Intrarenal BOLD MR images with sufficiently high resolution can be obtained on a human whole\u2010body scanner when combined with a small receiver coil to allow studies in mice. Both baseline R<jats:sub>2<\/jats:sub>* and \u0394R<jats:sub>2<\/jats:sub>* values following administration of furosemide were consistent with previous experience in humans and rats. J. Magn. Reson. Imaging 2007. \u00a9 2007 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.20841","type":"journal-article","created":{"date-parts":[[2007,2,5]],"date-time":"2007-02-05T18:22:54Z","timestamp":1170699774000},"page":"635-638","source":"Crossref","is-referenced-by-count":25,"title":["Evaluation of intrarenal oxygenation in mice by BOLD MRI on a 3.0T human whole\u2010body scanner"],"prefix":"10.1002","volume":"25","author":[{"given":"Lu\u2010Ping","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"Lindsay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pottumarthi V.","family":"Prasad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,2,5]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI113612"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.25.4.663"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.25.3.575"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.94.12.3271"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.20176"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.20043"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.rli.0000187166.43871.fb"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.20389"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.10301"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI1594"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.104.3.342"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.20590"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpa.2005.06.004"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2223010531"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199503093321006"},{"issue":"6","key":"e_1_2_6_17_2","first-page":"F1059","article-title":"Determinants of intrarenal oxygenation. 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