{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T07:53:30Z","timestamp":1769154810445,"version":"3.49.0"},"reference-count":38,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2007,2,26]],"date-time":"2007-02-26T00:00:00Z","timestamp":1172448000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2007,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To assess and compare biochemical and volumetric features of the cerebellum in patients with spinocerebellar ataxia type 2 (SCA2) and patients with the cerebellar variant of multiple system atrophy (MSA\u2010C).<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Nine genetically assigned SCA2 patients and six MSA\u2010C patients who met the clinical criteria of MSA\u2010C underwent a clinical and neuroradiological workup with respect to cerebellar features. The MR protocol consisted of a sagittal T1\u2010weighted three\u2010dimensional fast low\u2010angle shot (3D FLASH) sequence and a transversal T2\u2010 and spin\u2010density\u2010weighted turbo spin\u2010echo sequence. The proton magnetic resonance spectroscopic imaging (<jats:sup>1<\/jats:sup>H\u2010MRSI) protocol consisted of two chemical shift imaging (CSI) sequences (echo time (TE) = 20 and 135 msec).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Both short\u2010 and long\u2010TE MR spectroscopy (MRS) images showed significant decreases in values for <jats:italic>N<\/jats:italic>\u2010acetylaspartate to creatine (NAA\/Cr), and choline to creatine (Cho\/Cr) ratios in MSA\u2010C and SCA2 compared to normal controls, though there was no difference between the two patient groups. In contrast, distinct cerebellar lactate (Lac) peaks were detected in seven SCA2 patients, and small peaks were detected in two. However, we did not detect any definite Lac peak in MSA\u2010C or control subjects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>MRSI revealed Lac pathology in SCA2 but not in MSA\u2010C. Whether this indicates distinct pathogenetic mechanisms of cerebellar degeneration remains to be established. J. Magn. Reson. 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