{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T01:53:30Z","timestamp":1789955610793,"version":"4.0.1"},"reference-count":21,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2007,7,3]],"date-time":"2007-07-03T00:00:00Z","timestamp":1183420800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2007,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To assess the state and dynamics of the intracranial system in idiopathic normal\u2010pressure hydrocephalus (I\u2010NPH), we determined intracranial compliance using magnetic resonance imaging (MRI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>The intracranial compliance index (ICCI), which was defined as the ratio of the peak\u2010to\u2010peak intracranial volume change (ICVC<jats:sub>p\u2010p<\/jats:sub>) to the peak\u2010to\u2010peak cerebrospinal fluid (CSF) pressure gradient (PG<jats:sub>p\u2010p<\/jats:sub>) during the cardiac cycle, was obtained from the net transcranial blood and CSF flow measured with phase\u2010contrast (PC) cine MRI. ICCI was determined in patients with I\u2010NPH (<jats:italic>N<\/jats:italic> = 7), brain atrophy, or asymptomatic ventricular dilation (VD) (<jats:italic>N<\/jats:italic> = 6), and in healthy volunteers (control group; <jats:italic>N<\/jats:italic> = 11). The changes in ICCI indices were also analyzed after a CSF tap test (<jats:italic>N<\/jats:italic> = 2).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The ICCI in the I\u2010NPH group was significantly lower than in the control and VD groups, whereas no difference was found between the control and VD groups. The ICVC<jats:sub>p\u2010p<\/jats:sub> was also lower than in the control and VD groups. However, no significant difference was found in the PG<jats:sub>p\u2010p<\/jats:sub> between groups. The ICCI increased after the tap test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Intracranial compliance analysis with MRI makes it possible to noninvasively obtain more detailed information of intracranial biomechanics in the I\u2010NPH and to assist in the diagnosis of I\u2010NPH. J. Magn. Reson. Imaging 2007. \u00a9 2007 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.20999","type":"journal-article","created":{"date-parts":[[2007,7,4]],"date-time":"2007-07-04T13:52:37Z","timestamp":1183557157000},"page":"274-278","source":"Crossref","is-referenced-by-count":71,"title":["Noninvasive MRI assessment of intracranial compliance in idiopathic normal pressure 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