{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T02:57:14Z","timestamp":1761101834616},"reference-count":70,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2007,9,25]],"date-time":"2007-09-25T00:00:00Z","timestamp":1190678400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2007,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To determine the diagnostic performance of contrast\u2010enhanced MR angiography (CE\u2010MRA) with four doses of gadobenate dimeglumine for detection of significant steno\u2010occlusive disease of the carotid, renal, and pelvic vasculature.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Eighty\u2010four patients with suspected disease of the renal (<jats:italic>n<\/jats:italic> = 16), pelvic (<jats:italic>n<\/jats:italic> = 41), or carotid (<jats:italic>n<\/jats:italic> = 27) arteries underwent CE\u2010MRA (3D\u2010spoiled gradient\u2010echo sequences) at 1.5T. CE\u2010MRA was performed with gadobenate dimeglumine at 0.025, 0.05, 0.1, or 0.2 mmol\/kg (23, 24, 19, and 18 patients, respectively) administered at 2 mL\/sec. Accuracy, sensitivity, specificity, and positive and negative predictive values (PPV and NPV, respectively) for detection of significant disease (&gt;50% stenosis or occlusion for renal\/pelvic arteries; &gt;70% stenosis or occlusion for carotid arteries) was determined by three fully blinded, independent radiologists using conventional digital subtraction angiography (DSA) as reference standard. All comparisons were tested statistically (ANOVA, chi\u2010square, and Mantel\u2013Haenszel tests as appropriate) and reader agreement (kappa) was assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Values for accuracy, sensitivity, specificity, PPV, and NPV on CE\u2010MRA were consistently higher for 0.1 mmol\/kg gadobenate dimeglumine (accuracy = 95.2\u201397.3%, sensitivity = 84.2% (all readers), specificity = 96.9\u201399.2%, PPV = 80.0\u201394.1%, NPV = 97.6\u201397.7%). The greater accuracy of the 0.1 mmol\/kg dose was significant (<jats:italic>P<\/jats:italic> &lt; 0.01, all readers) compared to all other dose groups. Agreement between the three readers was good for all dose groups (kappa \u22650.58), with the highest percent agreement (85.7%) noted for the 0.1 mmol\/kg dose.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Significantly better diagnostic performance on CE\u2010MRA of the renal, pelvic, and carotid arteries is achieved with a gadobenate dimeglumine dose of 0.1 mmol\/kg bodyweight. J. Magn. Reson. Imaging 2007;26:1020\u20131032. \u00a9 2007 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.21127","type":"journal-article","created":{"date-parts":[[2007,9,25]],"date-time":"2007-09-25T16:46:56Z","timestamp":1190738816000},"page":"1020-1032","source":"Crossref","is-referenced-by-count":17,"title":["Gadobenate dimeglumine\u2010enhanced MR angiography: Diagnostic performance of four doses for detection and grading of carotid, renal, and aorto\u2010iliac stenoses compared to digital subtraction angiography"],"prefix":"10.1002","volume":"26","author":[{"given":"G\u00fcnther","family":"Schneider","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudio","family":"Ballarati","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luigi","family":"Grazioli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Riccardo","family":"Manfredi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siegfried","family":"Thurnher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas J.","family":"Kroencke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias","family":"Taupitz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Biagio","family":"Merlino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorenzo","family":"Bonomo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ningyan","family":"Shen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianpaolo","family":"Pirovano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miles A.","family":"Kirchin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Spinazzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,9,25]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004424-199712000-00009"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004728-199911001-00021"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.rli.0000197668.44926.f7"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.rli.0000184756.66360.d3"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.rli.0000192421.81037.d5"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2301021085"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-003-1128-4"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00247-004-1392-4"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2402051266"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.2007.106.4.557"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004424-200212000-00011"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.10313"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.220.2.r01au38484"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2271011989"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2342040023"},{"key":"e_1_2_5_17_2","first-page":"87","article-title":"Gadobenate dimeglumine (Gd\u2010BOPTA) vs. gadopentetate dimeglumine (Gd\u2010DTPA) for contrast\u2010enhanced magnetic resonance angiography (MRA): improvement in intravascular signal intensity and contrast to noise ratio","volume":"106","author":"Pediconi F","year":"2003","journal-title":"Radiol Med (Torino)"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004424-200308000-00005"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.179.6.1791573"},{"key":"e_1_2_5_20_2","unstructured":"MerlinoB HentrichH\u2010R Dapr\u00e0M KirchinMA BonomoL.Gadobenate dimeglumine in contrast enhanced magnetic resonance angiography of the carotid arteries. 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