{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T01:45:36Z","timestamp":1791683136305,"version":"4.3.4"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2007,11,16]],"date-time":"2007-11-16T00:00:00Z","timestamp":1195171200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2008,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To study the pharmacokinetic parameters derived from dynamic contrast\u2010enhanced magnetic resonance imaging (DCE\u2010MRI) of the patellar cartilage under normal and pathological conditions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>DCE\u2010MRI was obtained in 22 cases. There were 17 patients with degenerative patellar conditions (eight with chondromalacia and nine with osteoarthritis) and five normal subjects. The cartilage pharmacokinetic parameters of K<jats:sup>trans<\/jats:sup> (vascular permeability), k<jats:sub>ep<\/jats:sub> (extraction ratio), \u03c5<jats:sub>e<\/jats:sub> (extravascular extracellular space [EES] volume fraction), and \u03c5<jats:sub>p<\/jats:sub> (intravascular space volume fraction) were extracted.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Statistically significant differences were observed between the different groups (normal cartilage, chondromalacia and osteoarthritis) for K<jats:sup>trans<\/jats:sup> and \u03c5<jats:sub>e<\/jats:sub>. K<jats:sup>trans<\/jats:sup> values were (mean \u00b1 SD) 1.06 \u00b1 0.62, 11.97 \u00b1 8.91, and 21.21 \u00b1 16.03 mL \u00b7 minute<jats:sup>\u20131<\/jats:sup> \u00b7 100 mL<jats:sup>\u20131<\/jats:sup> (<jats:italic>P<\/jats:italic> &lt; 0.02), respectively; and \u03c5<jats:sub>e<\/jats:sub> values were 0.71 \u00b1 0.69, 3.59 \u00b1 2.21, and 10.51 \u00b1 8.20% (<jats:italic>P<\/jats:italic> &lt; 0.002). Reproducibility of the pharmacokinetic calculations was assessed with a second set of analyses of 10 random cases one week after the first analysis, showing a test\u2010retest root mean square (RMS) coefficient of variation of 9.78% for K<jats:sup>trans<\/jats:sup> and 14.72% for \u03c5<jats:sub>e<\/jats:sub>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The vascular permeability and EES fraction of cartilage increases with the severity of the degeneration. Pharmacokinetic models allow to study the vascular properties of the cartilage and may have applications as a surrogate index in longitudinal studies to quantify the evolution of drug trials. J. Magn. Reson. Imaging 2007. \u00a9 2007 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.21233","type":"journal-article","created":{"date-parts":[[2007,11,16]],"date-time":"2007-11-16T21:49:03Z","timestamp":1195249743000},"page":"171-177","source":"Crossref","is-referenced-by-count":28,"title":["MR pharmacokinetic modeling of the patellar cartilage differentiates normal from pathological conditions"],"prefix":"10.1002","volume":"27","author":[{"given":"Roberto","family":"Sanz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Mart\u00ed\u2010Bonmat\u00ed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Luis","family":"Rodrigo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Moratal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,11,16]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1148\/rg.235035113"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiographics.17.6.9397453"},{"key":"e_1_2_5_4_2","first-page":"641","article-title":"An\u00e1lisis de la perfusi\u00f3n del cart\u00edlago rotuliano mediante resonancia magn\u00e9tica din\u00e1mica: aplicaci\u00f3n en sujetos con dolor anterior de origen rotuliano. 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