{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T04:36:07Z","timestamp":1781152567357,"version":"3.54.1"},"reference-count":42,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2008,2,28]],"date-time":"2008-02-28T00:00:00Z","timestamp":1204156800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2008,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To evaluate the reproducibility of neural activations induced by an anticipatory anxiety provocation challenge in healthy volunteers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Fourteen healthy male volunteers participated in two separate functional MRI (fMRI) sessions in which they underwent a paradigm based on anticipation of aversive transcutaneous electrical nerve stimulations. This paradigm consisted of alternating presentation of red circles associated with the likelihood that aversive stimuli may be given and blue circles during which the subjects knew that no shock could be given. Anxiety state was compared before the fMRI sessions and during the threat periods using clinical scales (Hamilton, STAI\u2010Y1), the Bond and Lader Visual Analogue Scale, and self\u2010rating scales of apprehension and stimulus aversivity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The selected paradigm induced anticipatory anxiety of moderate intensity as suggested by clinical scales and apprehension rating, without any habituation to the somatosensory stimulus across sessions. Compared to rest periods, threat of the aversive stimulus induced clear brain activation in anticipatory anxiety\u2010related areas: frontal\/prefrontal cortex, insula, lentiform nucleus, temporal pole, and cingulate cortex. Anxiety symptoms and cerebral activity were reproducible across sessions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The fMRI paradigm and its assessment method include all criteria to speed up the evaluation and the development of new anxiolytics. J. Magn. Reson. Imaging 2008;27:459\u2013468. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.21237","type":"journal-article","created":{"date-parts":[[2008,2,28]],"date-time":"2008-02-28T17:17:42Z","timestamp":1204219062000},"page":"459-468","source":"Crossref","is-referenced-by-count":28,"title":["Test\u2013retest reliability of a functional MRI anticipatory anxiety paradigm in healthy volunteers"],"prefix":"10.1002","volume":"27","author":[{"given":"Th\u00e9r\u00e8se","family":"Schunck","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilles","family":"Erb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"Mathis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Jacob","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Gilles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Izzie Jacques","family":"Namer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dieter","family":"Meier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R\u00e9my","family":"Luthringer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,2,28]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"251","article-title":"Fear, panic, anxiety, and disorders of emotion","volume":"43","author":"Barlow DH","year":"1996","journal-title":"Nebraska Symp Motiv"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80475-4"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-4388(00)00078-7"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1300186"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2004.12.016"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0028-3932(71)90067-4"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0924-9338(97)83296-8"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1987.01800180093014"},{"key":"e_1_2_6_10_2","volume-title":"Manual for the state\u2010trait anxiety inventory (Form Y)","author":"Spielberger CD","year":"1983"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1006\/jmre.1998.1502"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2001.1037"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.158.6.955"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.10277"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1037\/0033-2909.86.2.420"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0197-2456(86)90034-6"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1098\/rspa.1998.0193"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.2044-8341.1959.tb00467.x"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.2044-8341.1974.tb02285.x"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.1999.0407"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.98.2.688"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.284.5422.1979"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2005.06.068"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2006.01.035"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.152.8.1180"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(98)00348-5"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006842-200007000-00014"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1989.01810060013003"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-200112210-00020"},{"key":"e_1_2_6_30_2","first-page":"8","article-title":"Neural circuitry of anxiety: evidence from structural and functional neuroimaging studies","volume":"37","author":"Cannistraro PA","year":"2003","journal-title":"Psychopharmacol Bull"},{"key":"e_1_2_6_31_2","first-page":"953","volume-title":"Neuropsychopharmacology: The fifth generation of progress","author":"Rauch SL","year":"2002"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(03)00724-4"},{"key":"e_1_2_6_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(02)01355-0"},{"key":"e_1_2_6_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(98)00282-0"},{"key":"e_1_2_6_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80476-6"},{"key":"e_1_2_6_36_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.19-24-10869.1999"},{"key":"e_1_2_6_37_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0193(200003)9:3<156::AID-HBM4>3.0.CO;2-Q"},{"key":"e_1_2_6_38_2","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.20116"},{"key":"e_1_2_6_39_2","first-page":"1317","article-title":"Test\u2010retest analysis with functional MR of the activated area in the human visual cortex","volume":"18","author":"Rombouts SA","year":"1997","journal-title":"AJNR Am J Neuroradiol"},{"key":"e_1_2_6_40_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1522-2586(199907)10:1<33::AID-JMRI5>3.0.CO;2-N"},{"key":"e_1_2_6_41_2","first-page":"1711","article-title":"Reliability of functional MR imaging with word\u2010generation tasks for mapping Broca's area","volume":"22","author":"Brannen JH","year":"2001","journal-title":"AJNR Am J Neuroradiol"},{"key":"e_1_2_6_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2005.06.005"},{"key":"e_1_2_6_43_2","doi-asserted-by":"publisher","DOI":"10.1159\/000077948"}],"container-title":["Journal of Magnetic Resonance Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjmri.21237","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmri.21237","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T10:29:52Z","timestamp":1697106592000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmri.21237"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,2,28]]},"references-count":42,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2008,3]]}},"alternative-id":["10.1002\/jmri.21237"],"URL":"https:\/\/doi.org\/10.1002\/jmri.21237","archive":["Portico"],"relation":{},"ISSN":["1053-1807","1522-2586"],"issn-type":[{"value":"1053-1807","type":"print"},{"value":"1522-2586","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,2,28]]}}}