{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T20:13:50Z","timestamp":1790108030829,"version":"4.0.1"},"reference-count":31,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2008,3,27]],"date-time":"2008-03-27T00:00:00Z","timestamp":1206576000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2008,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To validate a noninvasive quantitative MRI technique, the K<jats:sub>i<\/jats:sub> perfusion method, for myocardial perfusion in humans using <jats:sup>13<\/jats:sup>N\u2010ammonia PET as a reference method.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Ten healthy males (64 \u00b1 8 years) were examined with combined PET and MRI perfusion imaging at rest and during stress induced by dipyridamole in order to determine the myocardial perfusion reserve. Myocardial and blood time concentration curves obtained by Gd\u2010DTPA\u2010enhanced MRI and <jats:sup>13<\/jats:sup>N\u2010ammonia PET were fitted by a two\u2010compartment perfusion model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mean perfusion values (\u00b1SD) derived from the MRI method at rest and at hyperemia were 80 \u00b1 20 and 183 \u00b1 56 mL\/min\/100 g, respectively. The same data for PET were 71 \u00b1 16 and 203 \u00b1 67 mL\/min\/100 g. A linear relationship was observed between MRI and PET\u2010derived myocardial perfusion reserve for regional and global data. Linear regression for the global absolute perfusion reserve gave a correlation coefficient of 0.96 (<jats:italic>P<\/jats:italic> &lt; 0.004, y=0.83x\u20106.9). A good agreement between the two methods to determine low or high perfusion reserves was found.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our data provide validation of the perfusion marker K<jats:sub>i<\/jats:sub> derived by the MRI method as a quantitative marker for myocardial perfusion in healthy humans. J. Magn. Reson. Imaging 2008;27:818\u2013824. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.21306","type":"journal-article","created":{"date-parts":[[2008,3,27]],"date-time":"2008-03-27T16:48:35Z","timestamp":1206636515000},"page":"818-824","source":"Crossref","is-referenced-by-count":77,"title":["Quantification of MRI measured myocardial perfusion reserve in healthy humans: A comparison with positron emission tomography"],"prefix":"10.1002","volume":"27","author":[{"given":"Thomas","family":"Fritz\u2010Hansen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens D.","family":"Hove","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus 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