{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T04:23:15Z","timestamp":1793334195990,"version":"4.5.0"},"reference-count":43,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2008,2,26]],"date-time":"2008-02-26T00:00:00Z","timestamp":1203984000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2008,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To investigate whether regional brain volumes in adolescent idiopathic scoliosis (AIS) patients differ from matched control subjects as AIS subjects are reported to have poor performance on combined visual and proprioceptive testing and impaired postural balance in previous studies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Twenty AIS female patients with typical right\u2010convex thoracic curve (age range,11\u201318 years; mean, 14.1 years) and 26 female controls (mean age, 14.8 years) underwent three\u2010dimensional magnetization prepared rapid acquisition gradient echo (3D\u2010MPRAGE) MR imaging. Volumes of 99 preselected neuroanatomical regions were compared by statistical parametric mapping and atlas\u2010based hybrid warping.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Analysis of variance statistics revealed significant mean volumetric differences in 22 brain regions between AIS and controls. Ten regions were larger in AIS including the left frontal gyri and white matter in left frontal, parietal, and temporal regions, corpus callosum and brainstem. Twelve regions were smaller in AIS, including right\u2010sided descending white matter tracts (anterior and posterior limbs of the right internal capsule and the cerebral peduncle) and deep nucleus (caudate), bilateral perirhinal cortices, left hippocampus and amygdala, bilateral precuneus gyri, and left middle and inferior occipital gyri.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Regional brain volume difference in AIS subjects may help to explain neurological abnormalities in this group. J. Magn. Reson. Imaging 2008. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.21321","type":"journal-article","created":{"date-parts":[[2008,2,26]],"date-time":"2008-02-26T22:20:14Z","timestamp":1204064414000},"page":"732-736","source":"Crossref","is-referenced-by-count":49,"title":["MR analysis of regional brain volume in adolescent idiopathic scoliosis: Neurological manifestation of a systemic disease"],"prefix":"10.1002","volume":"27","author":[{"given":"Tianming","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Winnie C.W.","family":"Chu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geoffrey","family":"Young","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaiming","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benson H.Y.","family":"Yeung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gene C.W.","family":"Man","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wynnie W.M.","family":"Lam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen T.C.","family":"Wong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jack C.Y.","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,2,26]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1080\/03093640008726538"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-199506000-00001"},{"key":"e_1_2_5_4_2","first-page":"133","volume-title":"Moe's textbook of scoliosis and other spinal deformities","author":"Winter RB","year":"1995"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007632-198907000-00017"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/jor.1100040113"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/jor.1100110209"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.2519\/jospt.1997.26.2.60"},{"key":"e_1_2_5_9_2","first-page":"184","article-title":"Equilibrial dysfunction in scoliosis\u2014cause or effect?","volume":"2","author":"O'Beirne J","year":"1989","journal-title":"J Spinal Disord"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.3109\/17453677908991307"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.3109\/17453677908989768"},{"key":"e_1_2_5_12_2","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1302\/0301-620X.77B5.7559706","article-title":"Absent superficial abdominal reflexes in children with scoliosis. 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