{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T16:34:05Z","timestamp":1773160445677,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2008,5,26]],"date-time":"2008-05-26T00:00:00Z","timestamp":1211760000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2008,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To clarify the components primarily responsible for diffusion abnormalities in pancreatic cancerous tissue.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Subjects comprised 10 patients with surgically confirmed pancreatic cancer. Diffusion\u2010weighted (DW) echo\u2010planar imaging (b value = 0, 500 s\/mm<jats:sup>2<\/jats:sup>) was employed to calculate the apparent diffusion coefficient (ADC). ADC values of cancer and noncancerous tissue were calculated. Furthermore, ADC values of the cancer were compared with histopathological results.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean (\u00b1standard deviation) ADC value was significantly lower for tumor (1.27 \u00b1 0.52 \u00d7 10<jats:sup>\u22123<\/jats:sup> mm<jats:sup>2<\/jats:sup>\/s) than for noncancerous tissue (1.90 \u00b1 0.41 \u00d7 10<jats:sup>\u22123<\/jats:sup> mm<jats:sup>2<\/jats:sup>\/s, <jats:italic>P<\/jats:italic> &lt; 0.05). Histopathological examination showed similar proportions of fibrotic area, cellular component, necrosis, and mucin in each case. Regarding the density of fibrosis in cancer, three cases were classified in the loose fibrosis group and the remaining seven cases were classified in the dense fibrosis group. The mean ADC value was significantly higher in the loose fibrosis group (1.88 \u00b1 0.39 \u00d7 10<jats:sup>\u22123<\/jats:sup> mm<jats:sup>2<\/jats:sup>\/s) than in the dense fibrosis group (1.01 \u00b1 0.29 \u00d7 10<jats:sup>\u22123<\/jats:sup> mm<jats:sup>2<\/jats:sup>\/s, <jats:italic>P<\/jats:italic> &lt; 0.05). In quantitative analysis, ADC correlated well with the proportion of collagenous fibers (<jats:italic>r<\/jats:italic> = \u22120.87, <jats:italic>P<\/jats:italic> &lt; 0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Collagenous fibers may be responsible for diffusion abnormalities in pancreatic cancer. J. Magn. Reson. Imaging 2008;27:1302\u20131308. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.21340","type":"journal-article","created":{"date-parts":[[2008,5,27]],"date-time":"2008-05-27T02:16:43Z","timestamp":1211854603000},"page":"1302-1308","source":"Crossref","is-referenced-by-count":147,"title":["Apparent diffusion coefficient in pancreatic cancer: Characterization and histopathological 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