{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T15:14:12Z","timestamp":1773414852746,"version":"3.50.1"},"reference-count":40,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2008,5,26]],"date-time":"2008-05-26T00:00:00Z","timestamp":1211760000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2008,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To look for the presence and age\u2010dependence of late structural alterations of otherwise normal\u2010appearing cerebral gray and white matter after radiation and chemotherapy in adult survivors of acute lymphoblastic leukemia (ALL) during childhood.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>In a group of 13 adult survivors 17\u201337 years old, who had been treated by total brain radiation (18\u201324 Gy) and chemotherapy 16\u201328 years ago, prospective MR examinations including diffusion tensor imaging (DTI) were performed. Evaluation included volumetry, calculation of mean diffusivity (MD) and fractional anisotropy (FA), and comparison of results to an age\u2010matched control group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>DTI showed significantly reduced FA values in the temporal lobes (difference of 0.069 units, <jats:italic>P<\/jats:italic> &lt; 0.001), hippocampi (difference of 0.033 units, <jats:italic>P<\/jats:italic> &lt; 0.001), and thalami (difference of 0.046 units, <jats:italic>P<\/jats:italic> = 0.001), which were accompanied by significant white matter volume loss (difference of 92 cm<jats:sup>3<\/jats:sup>, <jats:italic>P<\/jats:italic> &lt; 0.001). Significant elevations of MD were limited to the temporal white matter (difference of 42 \u00d7 10<jats:sup>\u22126<\/jats:sup> mm<jats:sup>2<\/jats:sup>\/s, <jats:italic>P<\/jats:italic> = 0.005). Global and frontal white matter MD correlated negatively to increasing age of the survivors (<jats:italic>P<\/jats:italic> &lt; 0.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>With regard to structural white matter alterations, adult long\u2010term survivors of childhood ALL, who had received total brain radiation and chemotherapy, apparently show the same overall age dependence as controls. Follow\u2010up studies are needed for confirmation. J. Magn. Reson. Imaging 2008;27:1250\u20131255. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.21364","type":"journal-article","created":{"date-parts":[[2008,5,27]],"date-time":"2008-05-27T01:47:40Z","timestamp":1211852860000},"page":"1250-1255","source":"Crossref","is-referenced-by-count":47,"title":["Late structural alterations of cerebral white matter in long\u2010term survivors of childhood leukemia"],"prefix":"10.1002","volume":"27","author":[{"given":"Paulo 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