{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T12:38:28Z","timestamp":1789735108728,"version":"4.0.1"},"reference-count":20,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2008,5,26]],"date-time":"2008-05-26T00:00:00Z","timestamp":1211760000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2008,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To illustrate the evolution of brain perfusion\u2010weighted magnetic resonance imaging (PWI\u2010MRI) in severe neonatal hypoxic\u2010ischemic (HI) encephalopathy, and its possible relation to further neurodevelopmental outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Two term neonates with HI encephalopathy underwent an early and a late MRI, including PWI. They were followed until eight months of age. A total of three \u201cnormal controls\u201d were also included. Perfusion maps were obtained, and relative cerebral blood flow (rCBF) and cerebral blood volume (rCBV) values were measured.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared to normal neonates, a hyperperfusion (increased rCBF and rCBV) was present on early scans in the whole brain. On late scans, hyperperfusion persisted in cortical gray matter (normalization of rCBF and rCBV ratios in white matter and basal ganglia, but not in cortical gray matter). Diffusion\u2010weighted imaging (DWI) was normalized, and extensive lesions became visible on T2\u2010weighted images. Both patients displayed very abnormal outcome: Patient 2 with the more abnormal early and late hyperperfusion being the worst.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>PWI in HI encephalopathy did not have the same temporal evolution as DWI, and remained abnormal for more than one week after injury. This could be a marker of an ongoing mechanism underlying severe neonatal HI encephalopathy. Evolution of PWI might help to predict further neurodevelopmental outcome. J. Magn. Reson. Imaging 2008;27:1229\u20131234. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.21379","type":"journal-article","created":{"date-parts":[[2008,5,27]],"date-time":"2008-05-27T01:47:03Z","timestamp":1211852823000},"page":"1229-1234","source":"Crossref","is-referenced-by-count":30,"title":["Temporal evolution of MR perfusion in neonatal hypoxic\u2010ischemic encephalopathy"],"prefix":"10.1002","volume":"27","author":[{"given":"Pia","family":"Wintermark","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrien C.","family":"Moessinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Gudinchet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reto","family":"Meuli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,5,26]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2005-0620E"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nic.2005.10.003"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.58.4.542"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(03)00908-6"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004424-200002000-00008"},{"key":"e_1_2_5_7_2","first-page":"1713","article-title":"MR contrast enhancement of the normal neonatal brain","volume":"18","author":"Barkovich AJ","year":"1997","journal-title":"AJNR Am J Neuroradiol"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/fn.88.6.F525"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2004-0222"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910360510"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910360511"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0887-8994(99)00101-0"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2004.10.011"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2004.12.026"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000014208.05597.33"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.20460"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1177\/088307389501000608"},{"key":"e_1_2_5_18_2","first-page":"463","article-title":"MR imaging quantification of cerebellar growth following hypoxic\u2010ischemic injury to the neonatal brain","volume":"25","author":"Le Strange E","year":"2004","journal-title":"AJNR Am J Neuroradiol"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1203\/01.PDR.0000088071.30873.DA"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1203\/01.pdr.0000232785.00965.b3"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1203\/pdr.0b013e31803237f6"}],"container-title":["Journal of Magnetic Resonance Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjmri.21379","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmri.21379","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T12:39:35Z","timestamp":1697114375000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmri.21379"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,5,26]]},"references-count":20,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2008,6]]}},"alternative-id":["10.1002\/jmri.21379"],"URL":"https:\/\/doi.org\/10.1002\/jmri.21379","archive":["Portico"],"relation":{},"ISSN":["1053-1807","1522-2586"],"issn-type":[{"value":"1053-1807","type":"print"},{"value":"1522-2586","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,5,26]]}}}