{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T17:54:46Z","timestamp":1760982886026},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2008,12,18]],"date-time":"2008-12-18T00:00:00Z","timestamp":1229558400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2009,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To develop a <jats:sup>1<\/jats:sup>H magnetic resonance spectroscopic imaging (MRSI) sequence that can be used to image infants\/children at 3T and by combining it with diffusion tensor imaging (DTI) tractography, extract relevant metabolic information corresponding to the corticospinal tract (CST).<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>A fast 3D MRSI sequence was developed for pediatric neuroimaging at 3T using spiral k\u2010space readout and dual band RF pulses (32 \u00d7 32 \u00d7 8 cm field of view [FOV], 1 cc iso\u2010resolution, TR\/TE = 1500\/130, 6:24 minute scan). Using DTI tractography to identify the motor tracts, spectra were extracted from the CSTs and quantified. Initial data from infants\/children with suspected motor delay (<jats:italic>n<\/jats:italic> = 5) and age\u2010matched controls (<jats:italic>n<\/jats:italic> = 3) were collected and <jats:italic>N<\/jats:italic>\u2010acetylaspartate (NAA) ratios were quantified.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The average signal\u2010to\u2010noise ratio of the NAA peak from the studies was \u224822. Metabolite profiles were successfully acquired from the CST by using DTI tractography. Decreased NAA ratios in those with motor delay compared to controls of \u224810% at the CST were observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A fast and robust 3D MRSI technique targeted for pediatric neuroimaging has been developed. By combining with DTI tractography, metabolic information from the CSTs can be retrieved and estimated. By combining DTI and 3D MRSI, spectral information from various tracts can be obtained and processed. J. Magn. Reson. Imaging 2009;29:1\u20136. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.21394","type":"journal-article","created":{"date-parts":[[2008,12,24]],"date-time":"2008-12-24T18:33:00Z","timestamp":1230143580000},"page":"1-6","source":"Crossref","is-referenced-by-count":5,"title":["Fast 3D <sup>1<\/sup>H MRSI of the corticospinal tract in pediatric brain"],"prefix":"10.1002","volume":"29","author":[{"given":"Dong\u2010Hyun","family":"Kim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meng","family":"Gu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles","family":"Cunningham","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Albert","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fiona","family":"Baumer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Orit A.","family":"Glenn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel B.","family":"Vigneron","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel Mark","family":"Spielman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony James","family":"Barkovich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,12,18]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1987.tb32915.x"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910090110"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910300405"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.194.2.7529934"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.10057"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.20478"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910390606"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2005.05.018"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.698"},{"key":"e_1_2_5_11_2","first-page":"882","article-title":"Developmental delay in children: assessment with proton MR spectroscopy","volume":"23","author":"Filippi CG","year":"2002","journal-title":"AJNR Am J Neuroradiol"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0012162206000612"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.acra.2005.10.016"},{"key":"e_1_2_5_14_2","volume-title":"Magnetic resonance imaging","author":"Haacke E","year":"1999"},{"key":"e_1_2_5_15_2","unstructured":"GuM SpielmanD.Robust lipid suppression using multiple frequency selective pulses for brain spectroscopic imaging at 3T. 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