{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T12:38:28Z","timestamp":1789735108721,"version":"4.0.1"},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2008,9,26]],"date-time":"2008-09-26T00:00:00Z","timestamp":1222387200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2008,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To determine whether an early magnetic resonance imaging (MRI) study using perfusion\u2010weighted imaging (PWI) may define the pattern of brain injury in term neonatal hypoxic\u2013ischemic (HI) encephalopathy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Five newborns with HI encephalopathy or a marker of perinatal depression, and 2 controls underwent an early MRI (at 2 to 4 days), including PWI. Relative cerebral blood flow (rCBF) values were measured.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>On early (\u22644 days) PWI\u2010MRI, marked hyperperfusion was seen in areas of HI brain damage, allowing the classification of the children into different patterns according to the predominant site of injury: 1 with a \u201cnormal pattern\u201d; 1 with a \u201cwatershed pattern\u201d with increased rCBF ratios in white matter; 1 with a \u201cbasal ganglia pattern\u201d with increased rCBF ratios in basal ganglia; and 2 with a \u201ctotal cortical pattern\u201d with increased rCBF ratios in cortical gray matter, white matter, and basal ganglia. These patterns were confirmed in all infants on late (9 to 11 days) conventional MRI (T2\u2010weighted images) (4 of 5 patients) or on postmortem examination (1 of 5 patients).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>PWI is technically feasible in neonates with HI encephalopathy in a reproducible way, permitting comparisons between children. It provides a practical means to identify early after birth the future definitive ischemic areas that may be shown on conventional MRI only later. J. Magn. Reson. Imaging 2008;28:1019\u20131025. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.21525","type":"journal-article","created":{"date-parts":[[2008,9,27]],"date-time":"2008-09-27T00:56:52Z","timestamp":1222477012000},"page":"1019-1025","source":"Crossref","is-referenced-by-count":37,"title":["Perfusion\u2010weighted magnetic resonance imaging patterns of hypoxic\u2013ischemic encephalopathy in term neonates"],"prefix":"10.1002","volume":"28","author":[{"given":"Pia","family":"Wintermark","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrien C.","family":"Moessinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Gudinchet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reto","family":"Meuli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,9,26]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2004.12.026"},{"key":"e_1_2_5_3_2","first-page":"1713","article-title":"MR contrast enhancement of the normal neonatal brain","volume":"18","author":"Barkovich AJ","year":"1997","journal-title":"AJNR Am J Neuroradiol"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/fn.88.6.F525"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2004.10.011"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2004-0222"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.58.4.542"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(03)00908-6"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004424-200002000-00008"},{"key":"e_1_2_5_10_2","unstructured":"WintermarkP MoessingerAC AbdelmoumeneA GudinchetF Alamo MaestreLT MeuliR.Method to perform perfusion\u2010weighted MRI in neonates. 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