{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T02:57:47Z","timestamp":1761101867032},"reference-count":40,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2008,11,24]],"date-time":"2008-11-24T00:00:00Z","timestamp":1227484800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2008,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To compare a novel method, percent\u2010infarct\u2010mapping (PIM), with conventional delayed enhancement (DE) of contrast for accurate myocardial viability assessment. Contrary to signal intensity (SI), the longitudinal relaxation\u2010rate enhancement (\u0394R1) is an intrinsic parameter linearly proportional to the concentration of contrast agent (CA). Determining \u0394R1 voxel\u2010by\u2010voxel, after administering an infarct\u2010avid CA, allows determination of per\u2010voxel percentage of infarcted tissue. The feasibility of generating PIM is demonstrated in canine reperfused infarction using an infarct\u2010avid, persistent\u2010CA (PCA), (Gd)(ABE\u2010DTTA). PIM is compared to the DE method using Gd(DTPA), and both to triphenyltetrazolium chloride (TTC) staining histochemistry.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>In six dogs, 48 hours following closed\u2010chest, 180\u2010minute coronary occlusion, DE imaging was carried out. PCA was administered immediately thereafter. Pixel\u2010by\u2010pixel R1 maps of the entire left ventricle (LV) were generated 48 hours after PCA using inversion\u2010recovery with multiple inversion times. R1, \u0394R1, and percent\u2010infarct values were calculated voxel\u2010by\u2010voxel.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Significant correlations (<jats:italic>P<\/jats:italic> &lt; 0.01, R \u2265 0.8) were obtained for percent\u2010infarct\u2010per\u2010slice (PIS) determined by DE or PIM vs. those from corresponding TTC\u2010stained slices. Compared to TTC, DE overestimated PIS by 32 \u00b1 18%. PIM underestimated PIS by 2.5 \u00b1 4.9%. Infarction fraction overestimation was 29 \u00b1 6% of LV by DE, but only 1.0 \u00b1 2.3% by PIM. Errors with PIM were significantly smaller than those with DE. Infarct area determined by signal intensity was similarly overestimated whether using Gd(DTPA) or Gd(ABE\u2010DTTA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The \u0394R1\u2010based PIM method is highly reproducible and more accurate than DE for quantifying myocardial viability in vivo. J. Magn. Reson. Imaging 2008;28:1386\u20131392. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.21571","type":"journal-article","created":{"date-parts":[[2008,11,24]],"date-time":"2008-11-24T16:24:05Z","timestamp":1227543845000},"page":"1386-1392","source":"Crossref","is-referenced-by-count":7,"title":["Head\u2010to\u2010head comparison between delayed enhancement and percent infarct mapping for assessment of myocardial infarct size in a canine model"],"prefix":"10.1002","volume":"28","author":[{"given":"Bal\u00e1zs","family":"Ruzsics","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P\u00e1l","family":"Sur\u00e1nyi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P\u00e1l","family":"Kiss","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brigitta 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