{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:49:44Z","timestamp":1786978184154,"version":"build-2736575974"},"reference-count":20,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2009,2,25]],"date-time":"2009-02-25T00:00:00Z","timestamp":1235520000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2009,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To assess the role of vascular space occupancy (VASO) magnetic resonance imaging (MRI), a noninvasive cerebral blood volume (CBV)\u2010weighted technique, for evaluating CBV reactivity in patients with internal carotid artery (ICA) stenosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      VASO reactivity, defined as a signal change in response to hypercapnic stimulus (4\u2010second exhale, 14\u2010second breath\u2010hold), was measured in the left and right ICA flow territories in patients (\n                      <jats:italic>n<\/jats:italic>\n                      = 10) with varying degrees of unilateral and bilateral ICA stenosis and in healthy volunteers (\n                      <jats:italic>n<\/jats:italic>\n                      = 10).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Percent VASO reactivity was more negative (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.01) bilaterally in patients (ipsilateral: \u22123.6 \u00b1 1.5%; contralateral: \u22123.4 \u00b1 1.2%) compared with age\u2010matched controls (left: \u22121.9 \u00b1 0.6%; right: \u22121.9 \u00b1 0.8%). Owing to the nature of the VASO contrast mechanism, this more negative VASO reactivity was attributed to autoregulatory CBV effects in patients. A postbreath\u2010hold overshoot, which was absent in healthy volunteers, was observed unilaterally in a subset of patients.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>More negative VASO reactivity was observed in patients with ICA stenosis and may be a marker of autoregulatory effects. Furthermore, the postbreath\u2010hold overshoot observed in patients is consistent with compensatory microvascular vasoconstriction and may be a marker of hemodynamic impairment. Based on the results of this feasibility study, VASO should be useful for identifying CBV adjustments in patients with steno\u2010occlusive disease of the ICA. J. Magn. Reson. Imaging 2009;29:718\u2013724. \u00a9 2009 Wiley\u2010Liss, Inc.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jmri.21667","type":"journal-article","created":{"date-parts":[[2010,8,3]],"date-time":"2010-08-03T05:15:14Z","timestamp":1280812514000},"page":"718-724","source":"Crossref","is-referenced-by-count":25,"title":["Vascular space occupancy (VASO) cerebral blood volume\u2010weighted MRI identifies hemodynamic impairment in patients with carotid artery disease"],"prefix":"10.1002","volume":"29","author":[{"given":"Manus J.","family":"Donahue","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Jan van Laar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter C.M.","family":"van Zijl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert D.","family":"Stevens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeroen","family":"Hendrikse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,2,25]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.53.2.251"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.31.1.128"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000086465.41263.06"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awf047"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.280.12.1055"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.57.7.814"},{"key":"e_1_2_5_8_2","first-page":"1876","article-title":"Dynamic CT perfusion imaging with acetazolamide challenge for evaluation of patients with unilateral cerebrovascular steno\u2010occlusive disease","volume":"27","author":"Chen A","year":"2006","journal-title":"AJNR Am J Neuroradiol"},{"key":"e_1_2_5_9_2","first-page":"862","article-title":"Measurement of cerebral blood flow in chronic carotid occlusive disease: comparison of dynamic susceptibility contrast perfusion MR imaging with positron emission tomography","volume":"24","author":"Mukherjee P","year":"2003","journal-title":"AJNR Am J Neuroradiol"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1522-2586(199911)10:5<870::AID-JMRI36>3.0.CO;2-D"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.10519"},{"key":"e_1_2_5_12_2","article-title":"Hemodynamic changes after visual stimulation and breath\u2010holding provide evidence for an uncoupling of cerebral blood flow and volume from oxygen metabolism","author":"Donahue MJ","year":"2008","journal-title":"J Cereb Blood Flow Metab"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.20379"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.21072"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.21467"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.21427"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.21273"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.20.6.828"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.10659"},{"key":"e_1_2_5_20_2","unstructured":"DonahueMJ StevensRD de BoorderM PekarJJ van ZijlPem.Cerebral blood volume decreases demonstrated during breath\u2010hold with vascular\u2010space\u2010occupancy (VASO) and VASO\u2010FLAIR fMRI. The International Society for Magnetic Resonance in Medicine 16th Scientific Meeting and Exhibition2007; Berlin Abstract 617."},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2333031276"}],"container-title":["Journal of Magnetic Resonance Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjmri.21667","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmri.21667","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T20:31:30Z","timestamp":1696883490000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmri.21667"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,2,25]]},"references-count":20,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2009,3]]}},"alternative-id":["10.1002\/jmri.21667"],"URL":"https:\/\/doi.org\/10.1002\/jmri.21667","archive":["Portico"],"relation":{},"ISSN":["1053-1807","1522-2586"],"issn-type":[{"value":"1053-1807","type":"print"},{"value":"1522-2586","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,2,25]]}}}