{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T12:24:04Z","timestamp":1784291044829,"version":"3.55.0"},"reference-count":21,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2009,2,25]],"date-time":"2009-02-25T00:00:00Z","timestamp":1235520000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2009,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To measure the elastic properties of ex vivo porcine aortas in control and hypertensive groups using a phase contrast magnetic resonance imaging (MRI)\u2010based elastography technique.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Female domestic pigs were randomized to a normal control group (N; <jats:italic>n<\/jats:italic> = 5) or a renovascular hypertension group (HT; <jats:italic>n<\/jats:italic> = 5) for the duration of 3 months. Mean arterial pressure was significantly higher in the hypertension group than in the control group (173 \u00b1 12 vs. 115 \u00b1 11 mmHg, <jats:italic>P<\/jats:italic> \u2264 0.05). The animals were euthanized after 3 months of hypertension and abdominal aortas harvested. The ex vivo aortic samples were then examined using a phase\u2010contrast MRI\u2010based elastography technique.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The Young's modulus\u2010wall thickness product, a reflection of vascular stiffness, was significantly higher in the hypertension group than in the control group (0.571 \u00b1 0.080 vs. 0.419 \u00b1 0.026, <jats:italic>P<\/jats:italic> &lt; 0.05). Histological analysis and staining confirmed increased intima\u2010media thickness and collagen content in the hypertensive aorta, while elastin staining showed no difference.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The current study shows that MR elastography offers a method to study the physiologic changes in the arterial wall secondary to early hypertension. J. Magn. Reson. Imaging 2009;29:583\u2013587. \u00a9 2009 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.21702","type":"journal-article","created":{"date-parts":[[2010,7,9]],"date-time":"2010-07-09T16:46:13Z","timestamp":1278693973000},"page":"583-587","source":"Crossref","is-referenced-by-count":26,"title":["Phase\u2010contrast MRI\u2010based elastography technique detects early hypertensive changes in ex vivo porcine aortic wall"],"prefix":"10.1002","volume":"29","author":[{"given":"David A.","family":"Woodrum","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joerg","family":"Herrmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir","family":"Lerman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony J.","family":"Romano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lilach O.","family":"Lerman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard L.","family":"Ehman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,2,25]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jhh.1002120"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-8703(99)70313-3"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000060460.52916.D6"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjhyper.2004.10.009"},{"key":"e_1_2_5_6_2","first-page":"RA81","article-title":"Measurement and application of arterial stiffness in clinical research: focus on new methodologies and diabetes mellitus","volume":"9","author":"Woodman RJ","year":"2003","journal-title":"Med Sci Monit"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-7061(02)02966-7"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.20991"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.7569924"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.20137"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910360214"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.20607"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-197802000-00011"},{"key":"e_1_2_5_14_2","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1681\/ASN.V1071455","article-title":"Noninvasive evaluation of a novel swine model of renal artery stenosis","volume":"10","author":"Lerman LO","year":"1999","journal-title":"J Am Soc Nephrol"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000152606.34120.97"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000077477.40824.52"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1006\/jmra.1995.9959"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000232501.08576.73"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1361-8415(03)00038-0"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-7061(02)02962-X"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-7061(01)02326-3"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-5629(96)00211-6"}],"container-title":["Journal of Magnetic Resonance Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjmri.21702","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmri.21702","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T00:31:08Z","timestamp":1696897868000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmri.21702"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,2,25]]},"references-count":21,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2009,3]]}},"alternative-id":["10.1002\/jmri.21702"],"URL":"https:\/\/doi.org\/10.1002\/jmri.21702","archive":["Portico"],"relation":{},"ISSN":["1053-1807","1522-2586"],"issn-type":[{"value":"1053-1807","type":"print"},{"value":"1522-2586","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,2,25]]}}}