{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T00:53:24Z","timestamp":1783472004370,"version":"3.55.0"},"reference-count":45,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2009,7,23]],"date-time":"2009-07-23T00:00:00Z","timestamp":1248307200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2009,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To correlate pineal parenchyma volume (PP) to circadian melatonin profiles and to determine the 24\u2010hour melatonin per volume of pineal tissue (MLPV). Furthermore, we compared melatonin profiles of cystic and solid glands.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In 15 healthy male subjects (20\u201327 years) the PP was determined using high\u2010resolution magnetic resonance imaging (trueFISP, isotropic voxel: 0.8 mm<jats:sup>3<\/jats:sup>). Melatonin plasma concentrations (MC) were determined every 2 hours for 24 hours.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mean PP was 125 \u00b1 54 mm<jats:sup>3<\/jats:sup>. PP correlated linearly to maximum MC and to 24\u2010hour melatonin (<jats:italic>r<\/jats:italic> = 0.61 and <jats:italic>r<\/jats:italic> = 0.64, <jats:italic>P<\/jats:italic> &lt; 0.05) but not to minimum MC. The 24\u2010hour melatonin was 653 \u00b1 242.6 pg\/mL, MLPV was 5.8 \u00b1 2.3 pg\/mL*ml<jats:sup>\u22121<\/jats:sup>. Nine pineal glands were solid and six were cystic. PP of solid glands showed higher linear correlations to maximum melatonin, to 24\u2010hour melatonin, and to the slope of the melatonin increase of the curve (<jats:italic>P<\/jats:italic> &lt; 0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>PP correlates linearly to melatonin plasma concentrations in humans. MLPV displays similar interindividual differences as 24\u2010hour melatonin. PP of solid glands show better correlation to melatonin profiles than cystic. J. Magn. Reson. Imaging 2009. \u00a9 2009 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.21872","type":"journal-article","created":{"date-parts":[[2009,7,23]],"date-time":"2009-07-23T18:43:43Z","timestamp":1248374623000},"page":"499-505","source":"Crossref","is-referenced-by-count":57,"title":["Pineal volume and circadian melatonin profile in healthy volunteers: An interdisciplinary approach"],"prefix":"10.1002","volume":"30","author":[{"given":"Ingo","family":"N\u00f6lte","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann\u2010Theres","family":"L\u00fctkhoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boris A.","family":"Stuck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bj\u00f6rn","family":"Lemmer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Schredl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Findeisen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Groden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,7,23]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-079X.1995.tb00155.x"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1080\/07420520500464361"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0531-5565(01)00120-6"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(87)90720-7"},{"key":"e_1_2_6_6_2","first-page":"233","article-title":"Development of the pineal gland: measurement with MR","volume":"17","author":"Sumida M","year":"1996","journal-title":"AJNR"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01250040"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A0656"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/14.6.540"},{"key":"e_1_2_6_10_2","series-title":"Traumerinnerung [dream recall, author's translation]. 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