{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:47:09Z","timestamp":1786978029171,"version":"build-2736575974"},"reference-count":39,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2010,2,25]],"date-time":"2010-02-25T00:00:00Z","timestamp":1267056000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2010,3]]},"abstract":"Abstract<\/jats:title>\n \n Purpose:<\/jats:title>\n To investigate the diagnostic performance of diffusion\u2010weighted imaging (DWI) for mammographically and clinically occult breast lesions.<\/jats:p>\n <\/jats:sec>\n \n Materials and Methods:<\/jats:title>\n \n The study included 91 women with 118 breast lesions (91 benign, 12 ductal carcinoma in situ [DCIS], 15 invasive carcinoma) initially detected on dynamic contrast\u2010enhanced magnetic resonance imaging (DCE\u2010MRI) and assigned BI\u2010RADS category 3, 4, or 5. DWI was acquired with b = 0 and 600 s\/mm\n 2<\/jats:sup>\n . Lesion visibility was assessed on DWI. Apparent diffusion coefficient (ADC) values were compared between malignancies, benign lesions, and normal (no abnormal enhancement on DCE\u2010MRI) breast tissue, and the diagnostic performance of DWI was assessed based on ADC thresholding.\n <\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n Twenty\u2010four of 27 (89%) malignant and 74\/91 (81%) benign lesions were hyperintense on the b = 600 s\/mm\n 2<\/jats:sup>\n diffusion\u2010weighted images. Both DCIS (1.33 \u00b1 0.19 \u00d7 10\n \u22123<\/jats:sup>\n mm\n 2<\/jats:sup>\n \/s) and invasive carcinomas (1.30 \u00b1 0.27 \u00d7 10\n \u22123<\/jats:sup>\n mm\n 2<\/jats:sup>\n \/s) were lower in ADC than benign lesions (1.71 \u00b1 0.43 \u00d7 10\n \u22123<\/jats:sup>\n mm\n 2<\/jats:sup>\n \/s;\n P<\/jats:italic>\n < 0.001), and each lesion type was lower in ADC than normal tissue (1.90 \u00b1 0.38 \u00d7 10\n \u22123<\/jats:sup>\n mm\n 2<\/jats:sup>\n \/s,\n P<\/jats:italic>\n \u2264 0.001). Receiver operating curve (ROC) analysis showed an area under the curve (AUC) of 0.77, and sensitivity = 96%, specificity = 55%, positive predictive value (PPV) = 39%, and negative predictive value (NPV) = 98% for an ADC threshold of 1.60 \u00d7 10\n \u22123<\/jats:sup>\n mm\n 2<\/jats:sup>\n \/s.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n Many mammographically and clinically occult breast carcinomas were visibly hyperintense on diffusion\u2010weighted images, and ADC enabled differentiation from benign lesions. Further studies evaluating DWI while blinded to DCE\u2010MRI are necessary to assess the potential of DWI as a noncontrast breast screening technique. J. Magn. Reson. Imaging 2010;1:562\u2013570. \u00a9 2010 Wiley\u2010Liss, Inc.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/jmri.22078","type":"journal-article","created":{"date-parts":[[2010,2,25]],"date-time":"2010-02-25T19:15:30Z","timestamp":1267125330000},"page":"562-570","source":"Crossref","is-referenced-by-count":155,"title":["Differential diagnosis of mammographically and clinically occult breast lesions on diffusion\u2010weighted MRI"],"prefix":"10.1002","volume":"31","author":[{"given":"Savannah C.","family":"Partridge","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy B.","family":"DeMartini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brenda F.","family":"Kurland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter R.","family":"Eby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven W.","family":"White","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Constance D.","family":"Lehman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,2,25]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.3322\/canjclin.57.2.75"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa065447"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.168.2.3393671"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2432060131"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2462070368"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2482072039"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2463070432"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2472070823"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.2463\/mrms.6.21"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.3348\/kjr.2007.8.5.390"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11604-007-0128-4"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.10140"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.2463\/mrms.7.23"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004728-200211000-00033"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-007-0621-2"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.20643"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.10116"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.acra.2007.06.006"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.2463\/mrms.4.35"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.21570"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1097\/RCT.0b013e318165dc6b"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.292.11.1317"},{"key":"e_1_2_5_24_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2442060461"},{"key":"e_1_2_5_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)66481-1"},{"key":"e_1_2_5_26_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa031759"},{"key":"e_1_2_5_27_2","volume-title":"Breast imaging reporting and data system atlas (BI\u2010RADS Atlas)","author":"American College of Radiology (ACR)","year":"2003"},{"key":"e_1_2_5_28_2","doi-asserted-by":"crossref","unstructured":"KumarR AsmuthJC HannaK et al.Application of 3D registration for detecting lesions in magnetic resonance breast scans. 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