{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T05:43:53Z","timestamp":1777614233160,"version":"3.51.4"},"reference-count":40,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2010,4,23]],"date-time":"2010-04-23T00:00:00Z","timestamp":1271980800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2010,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose:<\/jats:title><jats:p>To develop a fully quantitative 4D transcatheter intraarterial perfusion (TRIP) magnetic resonance imaging (MRI) technique and prospectively test the hypothesis that quantitative 4D TRIP\u2010MRI can be used clinically to monitor intraprocedural liver tumor perfusion reductions during transcatheter arterial chemoembolization (TACE).<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods:<\/jats:title><jats:p>TACE was performed within an x\u2010ray digital subtraction angiography (DSA)\u2010MRI procedure suite in 16 patients with hepatocellular carcinoma. Quantitative 4D TRIP\u2010MRI with targeted radiofrequency field mapping and dynamic longitudinal relaxation rate mapping was used to monitor changes in tumor perfusion during TACE. First\u2010pass perfusion analysis was performed to produce intraprocedural blood flow (F\u03c1) maps. Mean liver tumor perfusions before and after TACE were compared with a paired <jats:italic>t<\/jats:italic>\u2010test (\u03b1 = 0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>Perfusion reductions were successfully measured with quantitative 4D TRIP\u2010MRI in 22 separate tumors during 18 treatment sessions. Mean tumor perfusion F\u03c1 decreased from 16.3 (95% confidence interval [CI]: 10.7\u201321.9) before TACE to 5.0 (95% CI: 3.5\u20136.5) (mL\/min\/100 mL) after TACE. Tumor perfusion reductions were statistically significant (<jats:italic>P<\/jats:italic> &lt; 0.0005), with a mean absolute perfusion change of 11.4 (95% CI: 5.6\u201317.1) (mL\/min\/100 mL) and a mean percentage reduction of 61.0% (95% CI: 48.3%\u201373.6%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p>Quantitative 4D TRIP\u2010MRI can be successfully performed within clinical interventional settings to monitor intraprocedural changes in liver tumor perfusion during TACE. J. Magn. Reson. 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