{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T20:43:32Z","timestamp":1762375412116},"reference-count":21,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2010,5,24]],"date-time":"2010-05-24T00:00:00Z","timestamp":1274659200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2010,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose:<\/jats:title><jats:p>To investigate the three\u2010dimensional (3D) fast\u2010recovery fast spin\u2010echo accelerated (FRFSE\u2010XL) sequence as a new application for measuring the intraorbital optic nerve (ION) mean cross\u2010sectional area in vivo and to determine its value within a commonly used high resolution imaging protocol.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods:<\/jats:title><jats:p>The entire ION was scanned in nine healthy volunteers (mean age 32 \u00b1 4 years) using the 3D FRFSE\u2010XL sequence and a commonly used high resolution short\u2010echo fast fluid\u2010attenuated inversion\u2010recovery (sTE fFLAIR) sequence with identical slice locations at 1.5T. The mean cross\u2010sectional area from both sequences was measured on a slice\u2010by\u2010slice basis from 3 mm behind the globe to the orbital apex. The reproducibility of both techniques was assessed from repeated scans (scan\u2010rescan) and repeated image analysis (intraobserver).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>Measurement of the mean cross\u2010sectional area of the anterior 9 mm segment of the ION was only possible using the 3D FRFSE\u2010XL sequence with a mean area of 11.6 \u00b1 2.2 mm<jats:sup>2<\/jats:sup> (scan rescan COV = 3.3 \u00b1 1.5, intraobserver COV = 2.4 \u00b1 0.02) whereas the remainder segment of the ION (i.e., 9 mm behind the globe to the orbital apex) could only be measured with the use of the sTE fFLAIR with a mean area of 8.5 \u00b1 1.7 mm<jats:sup>2<\/jats:sup> (scan rescan COV = 4.9 \u00b1 2.5 and intraobserver COV = 3.70 \u00b1 0.03).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p>The 3D FRFSE\u2010XL allows fast and reproducible measurement of the cross\u2010sectional area of the anterior 9mm segment of the ION, which is not possible using commonly used imaging sequences due to image degradation from motion, and is of complementary value to the existing imaging protocol for ION atrophy quantification. J. Magn. Reson. Imaging 2010;31:1486\u20131491. \u00a9 2010 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.22202","type":"journal-article","created":{"date-parts":[[2010,5,26]],"date-time":"2010-05-26T13:44:52Z","timestamp":1274881492000},"page":"1486-1491","source":"Crossref","is-referenced-by-count":11,"title":["A method for measuring the cross sectional area of the anterior portion of the optic nerve in vivo using a fast 3D MRI sequence"],"prefix":"10.1002","volume":"31","author":[{"given":"Marios C.","family":"Yiannakas","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia A.M.","family":"Wheeler\u2010Kingshott","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alaine M.","family":"Berry","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karyn","family":"Chappell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Henderson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Madhan","family":"Kolappan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David H.","family":"Miller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel J.","family":"Tozer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,5,24]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002340000450"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awh284"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1552-6569.2007.00136.x"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1191\/1352458502ms809oa"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-510X(99)00271-3"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2008.12.047"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.59.2.250"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004691-199409000-00005"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.03-1246"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002340050344"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.3171\/JNS\/2008\/109\/8\/0255"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A1027"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1186\/cc7006"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.rli.0000195820.98062.c5"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.06-1075"},{"key":"e_1_2_5_17_2","first-page":"1","volume-title":"Clinical neuro\u2010ophthalmology","author":"Walsh FB","year":"1969"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2382032065"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2003.10.019"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1148\/rg.287085031"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/119.3.701"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1177\/1352458508093617"}],"container-title":["Journal of Magnetic Resonance Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjmri.22202","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmri.22202","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T12:30:00Z","timestamp":1696854600000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmri.22202"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,5,24]]},"references-count":21,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2010,6]]}},"alternative-id":["10.1002\/jmri.22202"],"URL":"https:\/\/doi.org\/10.1002\/jmri.22202","archive":["Portico"],"relation":{},"ISSN":["1053-1807","1522-2586"],"issn-type":[{"value":"1053-1807","type":"print"},{"value":"1522-2586","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,5,24]]}}}