{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T07:03:25Z","timestamp":1789715005516,"version":"4.0.1"},"reference-count":66,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2010,10,28]],"date-time":"2010-10-28T00:00:00Z","timestamp":1288224000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2010,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To characterize changes in diffusion properties of liver using diffusion tensor imaging (DTI) in an experimental model of liver fibrosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Liver fibrosis was induced in Sprague\u2013Dawley rats (<jats:italic>n<\/jats:italic> = 12) by repetitive dosing of carbon tetrachloride (CCl<jats:sub>4<\/jats:sub>). The animals were examined with a respiratory\u2010gated single\u2010shot spin\u2010echo echo\u2010planar DTI protocol at 7 T before, 2 weeks after, and 4 weeks after CCl<jats:sub>4<\/jats:sub> insult. Apparent diffusion coefficient (ADC), directional diffusivities (ADC<jats:sub>\/\/<\/jats:sub> and ADC<jats:sub>\u27c2<\/jats:sub>), and fractional anisotropy (FA) were measured. Liver histology was performed with hematoxylin\u2010eosin staining and Masson's trichrome staining.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Significant decrease (<jats:italic>P<\/jats:italic> &lt; 0.01) in ADC was found at 2 weeks (0.86 \u00b1 0.09 \u00d7 10<jats:sup>\u22123<\/jats:sup> mm<jats:sup>2<\/jats:sup>\/s) and 4 weeks (0.74 \u00b1 0.09 \u00d7 10<jats:sup>\u22123<\/jats:sup> mm<jats:sup>2<\/jats:sup>\/s) following CCl<jats:sub>4<\/jats:sub> insult, as compared with that before insult (0.97 \u00b1 0.08 \u00d7 10<jats:sup>\u22123<\/jats:sup> mm<jats:sup>2<\/jats:sup>\/s). Meanwhile, FA at 2 weeks (0.18 \u00b1 0.03) after CCl<jats:sub>4<\/jats:sub> insult was significantly lower (<jats:italic>P<\/jats:italic> &lt; 0.01) than that before insult (0.26 \u00b1 0.05), and subsequently normalized at 4 weeks (0.26 \u00b1 0.07) after the insult. Histology showed collagen deposition, presence of intracellular fat vacuoles, and cell necrosis\/apoptosis in livers with CCl<jats:sub>4<\/jats:sub> insult.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>DTI detected the progressive changes in water diffusivities and diffusion anisotropy of liver tissue in this liver fibrosis model. ADC and FA are potentially valuable in detecting liver fibrosis at early stages and monitoring its progression. Future human studies are warranted to further verify the applicability of DTI in characterizing liver fibrosis and to determine its role in clinical settings. J. Magn. Reson. Imaging 2010;32:1141\u20131148. \u00a9 2010 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.22367","type":"journal-article","created":{"date-parts":[[2010,10,29]],"date-time":"2010-10-29T11:55:26Z","timestamp":1288353326000},"page":"1141-1148","source":"Crossref","is-referenced-by-count":43,"title":["Diffusion tensor imaging of liver fibrosis in an experimental model"],"prefix":"10.1002","volume":"32","author":[{"given":"Jerry S.","family":"Cheung","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu Juan","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darwin S.","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"April 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