{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T19:25:09Z","timestamp":1792697109695,"version":"4.5.0"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2011,5,23]],"date-time":"2011-05-23T00:00:00Z","timestamp":1306108800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2011,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose:<\/jats:title><jats:p>To investigate the correlation between MR elastography (MRE) assessed spleen stiffness and direct portal vein pressure gradient (D\u2010HVPG) measurements in a large animal model of portal hypertension.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods:<\/jats:title><jats:p>Cholestatic liver disease was established in adult canines by common bile duct ligation. A spin echo based echo planar imaging (EPI) MRE sequence was used to acquire three\u2010dimensional\/three axis (3D\/3\u2010axis) abdominal MRE data at baseline, 4 weeks, and 8 weeks. Liver biopsies, blood samples, and D\u2010HVPG measurements were obtained simultaneously.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>Animals developed portal hypertension (D\u2010HVPG: 11.0 \u00b1 5.1 mmHg) with only F1 fibrosis after 4 weeks. F3 fibrosis was confirmed after 8 weeks despite no further rise in portal hypertension (D\u2010HVPG: 11.3 \u00b1 3.2 mmHg). Mean stiffnesses of the spleen increased over two\u2010fold from baseline (1.72 \u00b1 0.33 kPa) to 4 weeks (3.54 \u00b1 0.31 kPa), and stabilized at 8 weeks (3.38 \u00b1 0.06 kPa) in a pattern consistent with changes in portal pressure. A positive correlation was observed between spleen stiffness and D\u2010HVPG (r<jats:sup>2<\/jats:sup>= 0.86;<jats:italic>P<\/jats:italic>&lt; 0.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p>These findings indicate a temporal relationship between portal hypertension and the development of liver fibrosis in a large animal model of cholestatic liver disease. The observed direct correlation between spleen stiffness and D\u2010HVPG suggest a noninvasive MRE approach to diagnose and screen for portal hypertension. J. Magn. Reson. 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