{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T18:41:03Z","timestamp":1790880063447,"version":"4.1.0"},"reference-count":22,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2011,7,18]],"date-time":"2011-07-18T00:00:00Z","timestamp":1310947200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2011,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose:<\/jats:title><jats:p>To assess optic nerve (ON) regeneration after injury by applying manganese\u2010enhanced MRI (MEMRI) in a study of comparative physiology between nonregenerating rat and mouse species and regenerating frog and fish species.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods:<\/jats:title><jats:p>The normal visual projections of rats, mice, frogs, and fish was visualized by intravitreal MnCl<jats:sub>2<\/jats:sub> injection followed by MRI. Rats and mice with ON crush (ONC) were divided into nonregenerating (ONC only), and regenerating animals with peripheral nerve graft (ONC+PNG; rats) or lens injury (ONC+LI; mice) and monitored by MEMRI at 1 and 20 days post\u2010lesion (dpl). Frog and fish with ON transection (ONT) were monitored by MEMRI up to 6 months postlesion (mpl).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>Signal intensity profiles of the Mn<jats:sup>2+<\/jats:sup>\u2010enhanced ON were consistent with ON regeneration in the ONC+PNG and ONC+LI rat and mice groups, respectively, compared with the nonregenerating ONC groups. Furthermore, signal intensity profiles of the Mn<jats:sup>2+<\/jats:sup>\u2010enhanced ON obtained between 1 mpl and 6 mpl in the fish and frog groups, respectively, were consistent with spontaneous, complete ON regeneration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p>Taken together, these results demonstrate that MEMRI is a viable method for serial, in vivo monitoring of normal, induced, and spontaneously regenerating optic nerve axons in different species. J. Magn. Reson. Imaging 2011;. \u00a9 2011 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.22631","type":"journal-article","created":{"date-parts":[[2011,7,18]],"date-time":"2011-07-18T15:02:12Z","timestamp":1311001332000},"page":"670-675","source":"Crossref","is-referenced-by-count":21,"title":["Axonal tracing of the normal and regenerating visual pathway of mouse, rat, frog, and fish using manganese\u2010enhanced MRI (MEMRI)"],"prefix":"10.1002","volume":"34","author":[{"given":"Axel","family":"Sandvig","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioanna","family":"Sandvig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Berry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d8ystein","family":"Olsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tina Bugge","family":"Pedersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Brekken","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marte","family":"Thuen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,7,18]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.6171034"},{"key":"e_1_2_5_3_2","first-page":"147","article-title":"Regeneration of axons in the visual system","volume":"26","author":"Berry M","year":"2008","journal-title":"Restor Neurol Neurosci"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1161566"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2603"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4340-10.2010"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.6271-09.2010"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1944.7.1.57"},{"key":"e_1_2_5_9_2","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1152\/jn.1945.8.1.15","article-title":"Restoration of vision after crossing the optic nerves and after contralateral transplantation of eye","volume":"8","author":"Sperry RW","year":"1945","journal-title":"J Neurophysiol"},{"key":"e_1_2_5_10_2","first-page":"307","article-title":"Selectivity in regeneration of the oculomotor nerve in the cichlid fish, Astronotus ocellatus","volume":"14","author":"Sperry RW","year":"1965","journal-title":"J Embryol Exp Morphol"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.121.3.367"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0270(00)00292-2"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.20400"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.21504"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.21606"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.21234"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910400515"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2003.07.009"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.937"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(94)90959-8"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1007086004022"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.22284"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(95)00605-2"}],"container-title":["Journal of Magnetic Resonance Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjmri.22631","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmri.22631","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T00:25:27Z","timestamp":1696897527000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmri.22631"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,7,18]]},"references-count":22,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2011,9]]}},"alternative-id":["10.1002\/jmri.22631"],"URL":"https:\/\/doi.org\/10.1002\/jmri.22631","archive":["Portico"],"relation":{},"ISSN":["1053-1807","1522-2586"],"issn-type":[{"value":"1053-1807","type":"print"},{"value":"1522-2586","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,7,18]]}}}