{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T16:19:04Z","timestamp":1781885944664,"version":"3.54.5"},"reference-count":20,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2011,9,23]],"date-time":"2011-09-23T00:00:00Z","timestamp":1316736000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2011,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose:<\/jats:title><jats:p>To investigate the water diffusion tensor properties of ex vivo tissue in the fibroid uterus, including the influence of degeneration, and the relevance of the principal eigenvector orientation to the underlying tissue structure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods:<\/jats:title><jats:p>Following hysterectomy, high\u2010resolution structural T<jats:sub>2<\/jats:sub>\u2010weighted and diffusion tensor magnetic resonance imaging (DT\u2010MRI) were performed on nine uteri at 7 T. Mean diffusivity (MD), fractional anisotropy (FA), and principal eigenvector orientation were measured in myometrium and in myxoid and dense tissue in fibroids. Imaging data and measurements of water diffusion parameters were compared with histopathology findings.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>The nine uteri yielded 23 fibroids. MD was 50% higher in regions of myxoid degeneration compared to dense fibroid tissue (<jats:italic>P<\/jats:italic> = 0.001), while myometrium was intermediate in value (dense fibroid tissue, <jats:italic>P<\/jats:italic> = 0.15; myxoid degeneration, <jats:italic>P<\/jats:italic> = 0.23). FA was lower in dense fibroid tissue than in myometrium (<jats:italic>P<\/jats:italic> = 3 \u00d7 10<jats:sup>\u22125<\/jats:sup>), but higher than in myxoid tissue (<jats:italic>P<\/jats:italic> = 0.003). Principal eigenvector orientation corresponded qualitatively with that of uterine smooth muscle fibers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p>The water diffusion tensor measured ex vivo in the fibroid uterus is a sensitive probe of tissue type, myxoid degeneration, and morphology. J. Magn. Reson. Imaging 2011;. \u00a9 2011 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.22793","type":"journal-article","created":{"date-parts":[[2011,9,27]],"date-time":"2011-09-27T23:38:23Z","timestamp":1317166703000},"page":"1445-1451","source":"Crossref","is-referenced-by-count":6,"title":["Ex vivo water diffusion tensor properties of the fibroid uterus at 7 T and their relation to tissue morphology"],"prefix":"10.1002","volume":"34","author":[{"given":"Michael J.","family":"Thrippleton","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark E.","family":"Bastin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirsty I.","family":"Munro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alistair R.","family":"Williams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anca","family":"Oniscu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurits A.","family":"Jansen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gavin D.","family":"Merrifield","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graham","family":"McKillop","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David E.","family":"Newby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott I.","family":"Semple","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian","family":"Marshall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hilary O.","family":"Critchley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,9,23]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmn006"},{"key":"e_1_2_6_3_2","first-page":"1","article-title":"Hysterectomy surveillance\u2014United States, 1980\u20131993","volume":"46","author":"Lepine LA","year":"1997","journal-title":"MMWR CDC Surveill Summ"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.1076"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/1531-8249(199902)45:2<265::AID-ANA21>3.0.CO;2-3"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.rct.0000146111.48570.64"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2361040312"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.21677"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-009-1471-x"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-007-0787-7"},{"key":"e_1_2_6_11_2","first-page":"272","article-title":"Steps towards a non\u2010invasive biomarker of uterine fibroid morphology","volume":"17","author":"Munro KI","year":"2010","journal-title":"Reprod Sci"},{"key":"e_1_2_6_12_2","unstructured":"ThrippletonMJ MunroKI BastinME et al.Diffusion tensor imaging at 7 Tesla as a probe of uterine fibroid morphology. 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