{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T08:54:53Z","timestamp":1768812893406,"version":"3.49.0"},"reference-count":26,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2011,10,26]],"date-time":"2011-10-26T00:00:00Z","timestamp":1319587200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2012,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose:<\/jats:title><jats:p>To develop safe and effective manganese(II) \u2010based biodegradable macromolecular MRI contrast agents.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods:<\/jats:title><jats:p>In this study, we synthesized and characterized two polydisulfide manganese(II) complexes, Mn\u2010DTPA cystamine copolymers and Mn\u2010EDTA cystamine copolymers, as new biodegradable macromolecular MRI contrast agents. The contrast enhancement of the two manganese\u2010based contrast agents were evaluated in mice bearing MDA\u2010MB\u2010231 human breast carcinoma xenografts, in comparison with MnCl<jats:sub>2<\/jats:sub>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>The T<jats:sub>1<\/jats:sub> and T<jats:sub>2<\/jats:sub> relaxivities were 4.74 and 10.38 mM<jats:sup>\u22121<\/jats:sup>s<jats:sup>\u22121<\/jats:sup> per manganese at 3T for Mn\u2010DTPA cystamine copolymers (M<jats:sub>n<\/jats:sub> = 30.50 kDa) and 6.41 and 9.72 mM<jats:sup>\u22121<\/jats:sup>s<jats:sup>\u22121<\/jats:sup> for Mn\u2010EDTA cystamine copolymers (M<jats:sub>n<\/jats:sub> = 61.80 kDa). Both polydisulfide Mn(II) complexes showed significant liver, myocardium and tumor enhancement.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p>The manganese\u2010based polydisulfide contrast agents have a potential to be developed as alternative non\u2010gadolinium contrast agents for MR cancer and myocardium imaging. J. Magn. Reson. Imaging 2012;35:737\u2010744. \u00a9 2011 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.22848","type":"journal-article","created":{"date-parts":[[2011,10,26]],"date-time":"2011-10-26T14:42:34Z","timestamp":1319640154000},"page":"737-744","source":"Crossref","is-referenced-by-count":21,"title":["Polydisulfide manganese(II) complexes as non\u2010gadolinium biodegradable macromolecular MRI contrast agents"],"prefix":"10.1002","volume":"35","author":[{"given":"Zhen","family":"Ye","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eun\u2010Kee","family":"Jeong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xueming","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingqian","family":"Tan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shouyu","family":"Yin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zheng\u2010Rong","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,10,26]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1021\/cr980440x"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.21969"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2008.12.061"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacr.2007.08.014"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.2174\/1389201043376607"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.945"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1021\/bc8004683"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.2174\/1389201043376571"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja801482d"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1039\/b902875g"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1021\/bc100573t"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.10656"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.2147\/nano.2006.1.1.31"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijch.201000016"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2006.03.006"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11095-006-9028-z"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1021\/mp900153f"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1021\/cr00081a003"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi00728a030"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910010407"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mri.2008.07.020"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1039\/b009242h"},{"key":"e_1_2_5_24_2","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1007\/s007750100265","article-title":"Relaxometric evaluation of novel manganese(II) complexes for application as contrast agents in magnetic resonance imaging","volume":"7","author":"Aime S","year":"2002","journal-title":"J Biol Inorg Chem"},{"key":"e_1_2_5_25_2","doi-asserted-by":"publisher","DOI":"10.1021\/ic049559g"},{"key":"e_1_2_5_26_2","article-title":"Revisiting an old friend: manganese\u2010based MRI contrast agents","author":"Pan D","year":"2010","journal-title":"Wiley Interdiscip Rev Nanomed Nanobiotechnol"},{"key":"e_1_2_5_27_2","doi-asserted-by":"publisher","DOI":"10.1021\/mp100054m"}],"container-title":["Journal of Magnetic Resonance Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjmri.22848","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmri.22848","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T17:16:17Z","timestamp":1696871777000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmri.22848"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,10,26]]},"references-count":26,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2012,3]]}},"alternative-id":["10.1002\/jmri.22848"],"URL":"https:\/\/doi.org\/10.1002\/jmri.22848","archive":["Portico"],"relation":{},"ISSN":["1053-1807","1522-2586"],"issn-type":[{"value":"1053-1807","type":"print"},{"value":"1522-2586","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,10,26]]}}}