{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T23:28:01Z","timestamp":1792452481870,"version":"4.5.0"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2011,11,1]],"date-time":"2011-11-01T00:00:00Z","timestamp":1320105600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2012,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose:<\/jats:title><jats:p>To develop an experimental approach for determining in vivo transverse relaxation rates (T<jats:sub>2<\/jats:sub>) of metabolites that are detected by spectral editing without using simulations, and to demonstrate this approach to measure the T<jats:sub>2<\/jats:sub> of \u03b3\u2010aminobutyric acid (GABA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods:<\/jats:title><jats:p>The proposed method first determines the TE\u2010dependence of the edited signals using measurements in a pure phantom solution (10 mM \u03b3\u2010aminobutyric acid; GABA); the phantom T<jats:sub>2<\/jats:sub> is also determined. Once the editing echo time (TE) \u2010modulation pattern is known, it can then be used to determine T<jats:sub>2<\/jats:sub> in vivo. The method was applied to measure GABA T<jats:sub>2<\/jats:sub> in the occipital lobe of five healthy adult subjects at 3T, using a J\u2010difference editing method. Unwanted macromolecular contributions to the GABA signal were also measured.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>The in vivo T<jats:sub>2<\/jats:sub> of edited GABA signal was 88 \u00b1 12 ms; this preliminary result is somewhat shorter than other metabolite T<jats:sub>2<\/jats:sub> values in the literature at this field strength.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p>Spectral editing methods are now widely used to detect low concentration metabolites, such as GABA, but to date no edited acquisition methods have been proposed for the measurement of transverse relaxation times (T<jats:sub>2<\/jats:sub>). The method described has been successfully applied to measuring the T<jats:sub>2<\/jats:sub> of GABA. J. Magn. Reson. Imaging 2012;35:229\u2010234. \u00a9 2011 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.22865","type":"journal-article","created":{"date-parts":[[2011,11,1]],"date-time":"2011-11-01T17:55:06Z","timestamp":1320170106000},"page":"229-234","source":"Crossref","is-referenced-by-count":82,"title":["Measuring T<sub>2<\/sub> in vivo with J\u2010difference editing: Application to GABA at 3 tesla"],"prefix":"10.1002","volume":"35","author":[{"given":"Richard A.E.","family":"Edden","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jarunee","family":"Intrapiromkul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"He","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter B.","family":"Barker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,11]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910360302"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1104"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.713"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910330215"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1213"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.20053"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.21250"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.21055"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.12.5662"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1522-2594(199908)42:2<283::AID-MRM10>3.0.CO;2-Q"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.10715"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.21234"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0900728106"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn2001"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2010.07.017"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4426-09.2009"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.6158-09.2010"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2010.09.003"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2559"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-1492(199810)11:6<266::AID-NBM530>3.0.CO;2-J"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.21996"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1522-2594(199904)41:4<649::AID-MRM2>3.0.CO;2-G"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910320304"},{"key":"e_1_2_7_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/1522-2594(200103)45:3<517::AID-MRM1068>3.0.CO;2-6"},{"key":"e_1_2_7_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.1205"},{"key":"e_1_2_7_27_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.21383"},{"key":"e_1_2_7_28_2","doi-asserted-by":"publisher","DOI":"10.1002\/1099-1492(200005)13:3<129::AID-NBM619>3.0.CO;2-V"},{"key":"e_1_2_7_29_2","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.1150"}],"container-title":["Journal of Magnetic Resonance Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjmri.22865","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmri.22865","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T10:58:51Z","timestamp":1696849131000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmri.22865"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,11]]},"references-count":28,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,1]]}},"alternative-id":["10.1002\/jmri.22865"],"URL":"https:\/\/doi.org\/10.1002\/jmri.22865","archive":["Portico"],"relation":{},"ISSN":["1053-1807","1522-2586"],"issn-type":[{"value":"1053-1807","type":"print"},{"value":"1522-2586","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,11]]}}}