{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T16:19:09Z","timestamp":1781885949086,"version":"3.54.5"},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2011,11,29]],"date-time":"2011-11-29T00:00:00Z","timestamp":1322524800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2012,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose:<\/jats:title><jats:p>To assess the feasibility and reproducibility of 3\u2010tesla diffusion tensor imaging (DTI) of the anal canal.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods:<\/jats:title><jats:p>DTI was performed in 25 men with no clinical history of anal canal disease undergoing MRI for prostate cancer. Analysis of fractional anisotropy (FA), relative anisotropy (RA), and apparent diffusion coefficient (ADC) were determined for the epithelial\/subepithelial layer, internal sphincter, external sphincter, and puborectalis. The directionality of diffusion was recorded from color\u2010coded tractography maps. Obturator internus and gluteus maximus served as reference muscles. Mean (SD) of values for FA, RA, and ADC were compared using analysis of variance. Intra and inter\u2010rater agreement and test reproducibility (n = 5) was assessed by Bland\u2010Altman statistics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>Mean (SD) for the epithelial\/subepithelial layer, internal, external sphincter, and puborectalis were as follows: FA: 0.283 (0.099); 0.337 (0.049); 0.415 (0.072); and 0.407 (0.062), respectively. RA: 0.241 (0.094); 0.292 (0.050); 0.371 (0.083); 0.361 (0.067), respectively; and ADC: 1.49 (0.23); 1.59 (0.19); 1.51 (0.28); and 1.54 (0.29) \u00d7 10<jats:sup>\u22123<\/jats:sup>mm<jats:sup>2<\/jats:sup>\/s, respectively. Good overall intra and inter\u2010rater agreement and test\u2013retest reproducibility was noted (coefficient of variation of 4.8\u201319.4% and 5.9\u201312.9%, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p>Anisotropy is evident in the anal canal with good inter\u2010rater agreement and test reproducibility. J. Magn. Reson. Imaging 2012;35:820\u2013826. \u00a9 2011 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.22873","type":"journal-article","created":{"date-parts":[[2011,12,1]],"date-time":"2011-12-01T08:11:00Z","timestamp":1322727060000},"page":"820-826","source":"Crossref","is-referenced-by-count":17,"title":["Diffusion tensor imaging of the anal canal at 3 tesla: Feasibility and reproducibility of anisotropy measures"],"prefix":"10.1002","volume":"35","author":[{"given":"Vicky","family":"Goh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"Tam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N. Jane","family":"Taylor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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