{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T12:56:35Z","timestamp":1789995395318,"version":"4.0.1"},"reference-count":25,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2012,1,26]],"date-time":"2012-01-26T00:00:00Z","timestamp":1327536000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2012,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose:<\/jats:title><jats:p>To evaluate a 1.5T magnetic resonance imaging (MRI) protocol, including a dedicated acquisition sequence and a postprocessing tool for the quantitative analysis of hepatic tissue perfusion. Estimated perfusion parameters and histological results based on the METAVIR classification were prospectively compared for hepatic fibrosis assessment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods:<\/jats:title><jats:p>The study protocol was approved by the experimentation Ethics Committee and informed consent was obtained. Sixteen patients (6 women, 10 men; average age, 52.4 \u00b1 14.8 years) with chronic liver diseases were prospectively enrolled after a liver biopsy. MS\u2010325 (paramagnetic blood pool agent)\u2010enhanced MRI was performed using a free\u2010breath 3D\u2010VIBE T<jats:sub>1w<\/jats:sub> sequence. Image volumes were registered by an automatic rigid method. Liver perfusion was modeled by a dual\u2010input\u2010one\u2010compartment model and quantitative perfusion parameters such as arterial, portal, and total perfusion mean transit time (MTT) and hepatic perfusion index (HPI) were obtained using in\u2010house developed software.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>Arterial perfusion increased with METAVIR stage, whereas portal perfusion decreased leading to an HPI increase with fibrosis stage. MTT increased with F3, F4. A nonparametric Mann\u2013Whitney test demonstrated that HPI and portal perfusion were relevant in discriminating between advanced and nonadvanced fibrosis, between fibrosis and cirrhosis, then between nonfibrosis and fibrosis (<jats:italic>P<\/jats:italic> &lt; 0.01). A strong correlation was found between portal perfusion fall\u2010off and HPI increase (<jats:italic>r<\/jats:italic> = \u22120.97; <jats:italic>P<\/jats:italic> &lt; 0.001). HPI and portal perfusion were strongly correlated with fibrosis stage (<jats:italic>r<\/jats:italic> = 0.83 and \u22120.88; <jats:italic>P<\/jats:italic> &lt; 0.001, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p>HPI and portal perfusion could be relevant indicators for the clinical follow\u2010up in patients with chronic liver diseases. J. Magn. Reson. Imaging 2012;35:1380\u20131387. \u00a9 2012 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.23594","type":"journal-article","created":{"date-parts":[[2012,1,26]],"date-time":"2012-01-26T16:34:17Z","timestamp":1327595657000},"page":"1380-1387","source":"Crossref","is-referenced-by-count":19,"title":["3D\u2010liver perfusion MRI with the MS\u2010325 blood pool agent: A noninvasive protocol to asses liver 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