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However, correlation between relaxation times and fibrosis stage has been controversial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods:<\/jats:title><jats:p>Liver fibrosis was induced in male adult C57BL\/6N mice (22\u201325 g; <jats:italic>n<\/jats:italic> = 12) by repetitive dosing of carbon tetrachloride (CCl<jats:sub>4<\/jats:sub>). The animals were examined with a series of spin\u2010echo (SE) images with varying TRs and multiecho SE imaging sequence at 7 T before and 2, 4, 6, and 8 weeks after CCl<jats:sub>4<\/jats:sub> insult. Hepatic <jats:italic>T<\/jats:italic><jats:sub>1<\/jats:sub> and <jats:italic>T<\/jats:italic><jats:sub>2<\/jats:sub> values were measured. Histology was performed with hematoxylin\u2010eosin staining and Masson's trichrome staining.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>Significant increase (<jats:italic>P<\/jats:italic> &lt; 0.001) in hepatic <jats:italic>T<\/jats:italic><jats:sub>1<\/jats:sub> was found at 2, 4, 6, and 8 weeks following CCl<jats:sub>4<\/jats:sub> insult as compared with that before insult. Meanwhile, hepatic <jats:italic>T<\/jats:italic><jats:sub>2<\/jats:sub> at 2, 4, 6, and 8 weeks after CCl<jats:sub>4<\/jats:sub> insult was significantly higher (<jats:italic>P<\/jats:italic> &lt; 0.001) than that before the insult. Liver histology showed collagen deposition, edema, and infiltration of inflammatory cells in livers with CCl<jats:sub>4<\/jats:sub> insult.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p>Both longitudinal and transverse relaxation times may serve as robust markers for liver fibrosis. With the advent of single breath\u2010hold sequences for MR relaxometry, quantitative mapping of relaxation times can be routinely and reliably performed in abdominal organs and hence may be valuable and robust in detecting liver fibrosis at early phase and monitoring its progression. J. Magn. Reson. Imaging 2012;36:152\u2013158. \u00a9 2012 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.23606","type":"journal-article","created":{"date-parts":[[2012,2,14]],"date-time":"2012-02-14T19:42:30Z","timestamp":1329248550000},"page":"152-158","source":"Crossref","is-referenced-by-count":72,"title":["Measurement of liver <i>T<\/i><sub>1<\/sub> and <i>T<\/i><sub>2<\/sub> relaxation times in an experimental mouse model of liver fibrosis"],"prefix":"10.1002","volume":"36","author":[{"given":"April M.","family":"Chow","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darwin S.","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu Juan","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongwei","family":"Qiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank Y.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwan","family":"Man","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ed X.","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,2,14]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199306243282508"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI24282"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2002.33367"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.03.001"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2004.30110.x"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2002.36800"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-2980.2008.00356.x"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002610000013"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2243011495"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/00002142-200206000-00003"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2392050505"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.21066"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.1030"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2402050606"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910190220"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3495(94)80775-1"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910330107"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.210.3.r99fe17617"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2261011904"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.20682"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-007-0785-9"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.21467"},{"key":"e_1_2_5_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.818"},{"key":"e_1_2_5_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.20344"},{"key":"e_1_2_5_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.20771"},{"key":"e_1_2_5_27_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11547-007-0149-1"},{"key":"e_1_2_5_28_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21747"},{"key":"e_1_2_5_29_2","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.07.2086"},{"key":"e_1_2_5_30_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.21461"},{"key":"e_1_2_5_31_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2493080080"},{"key":"e_1_2_5_32_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.21227"},{"key":"e_1_2_5_33_2","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.09.2436"},{"key":"e_1_2_5_34_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840080204"},{"key":"e_1_2_5_35_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-006-9143-z"},{"key":"e_1_2_5_36_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910310513"},{"key":"e_1_2_5_37_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00247-010-1874-5"},{"key":"e_1_2_5_38_2","unstructured":"GuimaraesAR SiqueiraL BolandG et al.T2 relaxation time as a surrogate marker of liver fibrosis. 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