{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T15:32:50Z","timestamp":1770823970300,"version":"3.50.1"},"reference-count":36,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2012,5,7]],"date-time":"2012-05-07T00:00:00Z","timestamp":1336348800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2012,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose:<\/jats:title><jats:p>To evaluate intrinsic hepatic enhancement patterns on multiphase, gadolinium\u2010enhanced, fat\u2010suppressed, 3D T1\u2010weighted, gradient echo magnetic resonance imaging (MRI) as a quantitative correlate for severity of pathological changes in chronic liver disease (CLD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods:<\/jats:title><jats:p>This study was HIPAA\u2010compliant and Institutional Review Board\u2010approved. In all, 75 patients were studied by contrast\u2010enhanced multiphase abdominal MRI. CLD patients had liver histology correlation derived from right lobe liver biopsies. Contrast\u2010enhanced arterial\u2010 and delayed\u2010phase 3D gradient recalled echo (GRE) liver MRI were scored using feature categorization templates to quantify enhancement patterns by three independent readers. Liver histopathology was staged\/graded for fibrosis\/inflammation using the Scheuer system. Statistical testing for MRI histology correlates used a Pearson's product moment correlation and a Wilcoxon\u2013Mann\u2013Whitney two\u2010sample rank\u2010sum test. Reader agreement was analyzed by a modified Fleiss' kappa test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>MRI histology correlation was high for delayed\u2010phase MRI versus fibrosis stage (95% confidence interval [CI] 0.941 &lt; <jats:italic>r<\/jats:italic> &lt; 0.976, <jats:italic>P<\/jats:italic> = 5 \u00d7 10<jats:sup>\u22127<\/jats:sup>), but lower for all other comparisons (delayed\u2010phase vs. inflammation and arterial\u2010phase vs. inflammation or fibrosis all showed a CI no greater than 0.64). Paired testing between delayed\u2010phase MRI score and histology fibrosis staging incremental levels was significant (from <jats:italic>P<\/jats:italic> &lt; 10<jats:sup>\u22122<\/jats:sup> to <jats:italic>P<\/jats:italic> &lt; 10<jats:sup>\u22125<\/jats:sup>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p>A standard gadolinium\u2010enhanced liver MRI may provide a correlate measure of hepatic fibrosis over a spectrum of severity. J. Magn. Reson. Imaging 2012;36:422\u2013429. \u00a9 2012 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.23668","type":"journal-article","created":{"date-parts":[[2012,5,7]],"date-time":"2012-05-07T19:00:23Z","timestamp":1336417223000},"page":"422-429","source":"Crossref","is-referenced-by-count":16,"title":["Liver MRI and histological correlates in chronic liver disease on multiphase gadolinium\u2010enhanced 3D gradient echo imaging"],"prefix":"10.1002","volume":"36","author":[{"given":"Diego 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