{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T05:35:16Z","timestamp":1761975316353},"reference-count":36,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2012,7,12]],"date-time":"2012-07-12T00:00:00Z","timestamp":1342051200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2012,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose:<\/jats:title><jats:p>To evaluate the vasodilatory response of normal human brain and meningiomas under repeated breathholding challenges using vascular space occupancy (VASO) MRI at 3 Tesla (T).<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods:<\/jats:title><jats:p>Five normal volunteers and five patients with meningiomas were recruited for this study. For the normal group, VASO MRI during repeated breathholds of different duration (5 to 30 s) was acquired. Patients performed a 15\u2010s breathhold paradigm for VASO MRI. The maximum signal change and full\u2010width at half\u2010maximum (FWHM) were determined by curve fitting.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>Significant VASO signal decreases in the gray matter could be detected for a breathhold period as short as 5 s. The fractional activation volume vs. breathhold duration reached a plateau around 34.21 \u00b1 3.39% at 15 s. In the patient group, there were significant VASO signal decreases in normal gray matters and also in small areas of three large\u2010sized meningiomas.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p>The 3T VASO MRI detected significant signal decreases in the gray matter, but not in the white matter, during short periods of breathholding. The fractional activation volume reached the plateau at 15\u2010s breathhold, which is recommended for clinical application. J. Magn. Reson. Imaging 2012;36:1179\u20131185. \u00a9 2012 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.23745","type":"journal-article","created":{"date-parts":[[2012,7,13]],"date-time":"2012-07-13T16:22:25Z","timestamp":1342196545000},"page":"1179-1185","source":"Crossref","is-referenced-by-count":4,"title":["Vascular space occupancy MRI during breathholding at 3 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