{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T00:09:34Z","timestamp":1783469374541,"version":"3.55.0"},"reference-count":24,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2012,7,30]],"date-time":"2012-07-30T00:00:00Z","timestamp":1343606400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2012,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose:<\/jats:title><jats:p>To develop and evaluate a quantitative parameter for staging hepatic fibrosis by contrast enhancement signal intensity and morphological measurements from gadoxetic acid (Gd\u2010EOB\u2010DTPA)\u2010enhanced MR imaging.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods:<\/jats:title><jats:p>MR images were obtained in 93 patients; 75 patients had histopathologically proven hepatic fibrosis and 18 patients who had healthy livers were evaluated. The liver\u2010to\u2010muscle signal intensity ratio (SI<jats:sub>post<\/jats:sub> = SIliver\/SImuscle), contrast enhancement index (CEI = SIpost\/SIpre), and liver\u2010to\u2010spleen volumetric ratio (VR = Vliver\/Vspleen) were evaluated for staging hepatic fibrosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>VR was most strongly correlated with fibrosis stage (7.21; <jats:italic>r<\/jats:italic> = \u22120.83; <jats:italic>P<\/jats:italic> &lt; 0.001). Sensitivity, specificity, and area under the ROC curve demonstrated by linear regression formula generated by VR and CEI in predicting fibrous scores were 100%, 73%, and 0.91, respectively, for the detection of hepatic fibrosis F1 or greater (\u2265 F1),100%, 87%, and 0.96 for \u2265 F2, 74%, 98%, and 0.93 for \u2265 F3 and 91%, 100%, and 0.97 for F4.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p>The liver\u2010to\u2010spleen volumetric ratio and contrast enhancement index were reliable biomarkers for the staging of hepatic fibrosis on Gd\u2010EOB\u2010DTPA\u2010enhanced MR imaging. J. Magn. Reson. Imaging 2012;36:1148\u20131153. \u00a9 2012 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.23758","type":"journal-article","created":{"date-parts":[[2012,7,30]],"date-time":"2012-07-30T21:08:37Z","timestamp":1343682517000},"page":"1148-1153","source":"Crossref","is-referenced-by-count":58,"title":["Gd\u2010EOB\u2010DTPA\u2010enhanced MR imaging: Prediction of hepatic fibrosis stages using liver contrast enhancement index and liver\u2010to\u2010spleen volumetric ratio"],"prefix":"10.1002","volume":"36","author":[{"given":"Satoshi","family":"Goshima","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayuki","family":"Kanematsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruo","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Kondo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Kawada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriyuki","family":"Moriyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyongtae T.","family":"Bae","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,7,30]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2004.30110.x"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2002.06038.x"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.20771"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.20344"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21747"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.09.2436"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2463070077"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2452061673"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2402050606"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.21561"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.1880070413"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.183.1.1549695"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0928-4346(96)00325-8"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910220214"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.195.3.7754011"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.190.3.8115623"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2243011495"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.10100621"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.07.2181"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.135.2.7367613"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.161.2.3532188"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004728-198601000-00009"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.15.3298"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-008-2202-9"}],"container-title":["Journal of Magnetic Resonance Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjmri.23758","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmri.23758","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T10:40:52Z","timestamp":1696934452000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmri.23758"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,7,30]]},"references-count":24,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2012,11]]}},"alternative-id":["10.1002\/jmri.23758"],"URL":"https:\/\/doi.org\/10.1002\/jmri.23758","archive":["Portico"],"relation":{},"ISSN":["1053-1807","1522-2586"],"issn-type":[{"value":"1053-1807","type":"print"},{"value":"1522-2586","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,7,30]]}}}