{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T15:40:39Z","timestamp":1787499639612,"version":"build-2736575974"},"reference-count":43,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,9,12]],"date-time":"2012-09-12T00:00:00Z","timestamp":1347408000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>To detect radiation\u2010induced changes of temporal lobe normal\u2010appearing white mater (NAWM) following radiation therapy (RT) for nasopharyngeal carcinoma (NPC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>\n                      Seventy\u2010five H\n                      <jats:sup>1<\/jats:sup>\n                      \u2010MR spectroscopy and diffusion\u2010tensor imaging (DTI) examinations were performed in 55 patients before and after receiving fractionated radiation therapy (total dose; 66\u201375GY). We divided the dataset into six groups, a pre\u2010RT control group and five other groups based on time after completion of RT. N\u2010acetylaspartic acid (NAA)\/choline (Cho), NAA\/creatine (Cr), Cho\/Cr, mean diffusibility (MD), functional anisotropy (FA), radial diffusibility (\u03bb\n                      <jats:sub>\u27c2<\/jats:sub>\n                      ), and axial diffusibility (\u03bb\n                      <jats:sub>||<\/jats:sub>\n                      ) were calculated.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      NAA\/Cho and NAA\/Cr decreased and \u03bb\n                      <jats:sub>\u27c2<\/jats:sub>\n                      increased significantly within 1 year after RT compared with pre\u2010RT. After 1 year, NAA\/Cho, NAA\/Cr, and \u03bb\n                      <jats:sub>\u27c2<\/jats:sub>\n                      were not significantly different from pre\u2010RT. In all post\u2010RT groups, FA decreased significantly. \u03bb\n                      <jats:sub>||<\/jats:sub>\n                      decreased within 9 months after RT compared with pre\u2010RT, but was not significantly different from pre\u2010RT more than 9 months after RT.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>\n                      DTI and H\n                      <jats:sup>1<\/jats:sup>\n                      \u2010MR spectroscopy can be used to detect early radiation\u2010induced changes of temporal lobe NAWM following radiation therapy for NPC. Metabolic alterations and water diffusion characteristics of temporal lobe NAWM in patients with NPC after RT were dynamic and transient. J. Magn. Reson. Imaging 2013;37:101\u2013108. \u00a9 2012 Wiley Periodicals, Inc.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jmri.23788","type":"journal-article","created":{"date-parts":[[2012,9,12]],"date-time":"2012-09-12T10:46:41Z","timestamp":1347446801000},"page":"101-108","source":"Crossref","is-referenced-by-count":40,"title":["<sup>1<\/sup>\n                    H\u2010MR spectroscopy and diffusion tensor imaging of normal\u2010appearing temporal white matter in patients with nasopharyngeal carcinoma after irradiation: Initial experience"],"prefix":"10.1002","volume":"37","author":[{"given":"Wei Feng","family":"Xiong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi Jun","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong Zhuo","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao Fei","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,9,12]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197909)44:3<1029::AID-CNCR2820440335>3.0.CO;2-5"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19880415)61:8<1535::AID-CNCR2820610809>3.0.CO;2-E"},{"key":"e_1_2_5_4_2","first-page":"45","article-title":"Radiation injury of the brain","volume":"12","author":"Valk PE","year":"1991","journal-title":"AJNR Am J Neuroradiol"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1259\/0007-1285-65-778-918"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/00019052-200112000-00008"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.04.0933"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-007-9341-3"},{"key":"e_1_2_5_9_2","first-page":"1316","article-title":"Proton MR spectroscopic evaluation of suspicious brain lesions after stereotactic radiotherapy","volume":"22","author":"Schlemmer HP","year":"2001","journal-title":"AJNR Am J Neuroradiol"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1522-2586(199908)10:2<130::AID-JMRI4>3.0.CO;2-R"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2006.06.001"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.20017"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(03)00327-4"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(97)00714-1"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(95)02011-Y"},{"key":"e_1_2_5_16_2","first-page":"2200","article-title":"Evaluation of treatment\u2010induced cerebral white matter injury by using diffusion\u2010tensor MR imaging: initial experience","volume":"26","author":"Kitahara S","year":"2005","journal-title":"AJNR Am J Neuroradiol"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A0797"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2223010311"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.09090428"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.212.2.r99au42475"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/1531-8249(200003)47:3<391::AID-ANA20>3.0.CO;2-J"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0720-048X(99)00053-4"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.rct.0000161422.95625.8a"},{"key":"e_1_2_5_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.21657"},{"key":"e_1_2_5_25_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2000.0740254.x"},{"key":"e_1_2_5_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.20150"},{"key":"e_1_2_5_27_2","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.1443"},{"key":"e_1_2_5_28_2","doi-asserted-by":"publisher","DOI":"10.1667\/RR3494.1"},{"key":"e_1_2_5_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(01)01513-9"},{"key":"e_1_2_5_30_2","doi-asserted-by":"publisher","DOI":"10.1259\/bjr.73.868.10844868"},{"key":"e_1_2_5_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(94)00655-5"},{"key":"e_1_2_5_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2007.08.020"},{"key":"e_1_2_5_33_2","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2002.1267"},{"key":"e_1_2_5_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2003.07.005"},{"key":"e_1_2_5_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2005.01.028"},{"key":"e_1_2_5_36_2","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.20742"},{"key":"e_1_2_5_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(94)01335-F"},{"key":"e_1_2_5_38_2","first-page":"734","article-title":"Diffusion\u2010tensor imaging for the detection and quantification of treatment\u2010induced white matter injury in children with medulloblastoma: a pilot study","volume":"24","author":"Khong PL","year":"2003","journal-title":"AJNR Am J Neuroradiol"},{"key":"e_1_2_5_39_2","doi-asserted-by":"publisher","DOI":"10.1667\/RR3116"},{"key":"e_1_2_5_40_2","first-page":"1491","article-title":"Investigation of apparent diffusion coefficient and diffusion tensor anisotropy in acute and chronic multiple sclerosis lesions","volume":"20","author":"Tievsky AL","year":"1999","journal-title":"Am J Neuroradiol"},{"key":"e_1_2_5_41_2","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.782"},{"key":"e_1_2_5_42_2","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A0700"},{"key":"e_1_2_5_43_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11604-007-0209-4"},{"key":"e_1_2_5_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(99)00236-9"}],"container-title":["Journal of Magnetic Resonance Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjmri.23788","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmri.23788","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,8]],"date-time":"2023-10-08T16:21:57Z","timestamp":1696782117000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmri.23788"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,9,12]]},"references-count":43,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,1]]}},"alternative-id":["10.1002\/jmri.23788"],"URL":"https:\/\/doi.org\/10.1002\/jmri.23788","archive":["Portico"],"relation":{},"ISSN":["1053-1807","1522-2586"],"issn-type":[{"value":"1053-1807","type":"print"},{"value":"1522-2586","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,9,12]]}}}