{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T14:27:52Z","timestamp":1777645672282,"version":"3.51.4"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,9,17]],"date-time":"2012-09-17T00:00:00Z","timestamp":1347840000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose:<\/jats:title><jats:p>To determine brain tissue affected by dystonia by making group comparison of parameter\u2010based diffusion tensor imaging (DTI) distributions of patients with control subjects. A 2D distribution analysis of mean diffusivity and fractional anisotropy index was used for modeling brain tissues according to the inherent diffusion characteristics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods:<\/jats:title><jats:p>Seven affected carriers of the DYT1 dystonia mutation and eight healthy control subjects were imaged for a previous study. We employed a 2D distribution analysis of all the diffusion voxels and a four compartmental brain model for group comparison of the dystonia subjects and controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>Our analysis showed disease involvement in the white matter of the patients. Excellent tissue characterization was achieved automatically using the 2D distribution analysis based on a physical brain model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p>This 2D analysis implicated white matter in dystonia and could be useful as a screening tool in diseases with unknown pathologies. J. Magn. Reson. Imaging 2013;37:59\u201366. \u00a9 2012 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.23805","type":"journal-article","created":{"date-parts":[[2012,9,17]],"date-time":"2012-09-17T19:01:40Z","timestamp":1347908500000},"page":"59-66","source":"Crossref","is-referenced-by-count":10,"title":["White matter changes in primary dystonia determined by 2D distribution analysis of diffusion tensor images"],"prefix":"10.1002","volume":"37","author":[{"given":"An","family":"Vo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Eidelberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aziz M.","family":"Ulu\u01e7","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,9,17]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.1076"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.783"},{"key":"e_1_2_6_4_2","first-page":"1078","article-title":"Diffusion changes in the aging human brain","volume":"21","author":"Chun T","year":"2000","journal-title":"AJNR Am J Neuroradiol"},{"key":"e_1_2_6_5_2","first-page":"952","article-title":"Mean diffusivity and fractional anisotropy histograms of patients with multiple sclerosis","volume":"22","author":"Cercignani M","year":"2001","journal-title":"AJNR Am J Neuroradiol"},{"key":"e_1_2_6_6_2","unstructured":"UlugAM.Distribution analysis of diffusion tensor data. 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