{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T18:07:56Z","timestamp":1787162876602,"version":"build-2736575974"},"reference-count":43,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,10,10]],"date-time":"2012-10-10T00:00:00Z","timestamp":1349827200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>\n                      To investigate human brain metabolite discriminability and general measurement reproducibility of two\u2010dimensional (2D)\n                      <jats:italic>J<\/jats:italic>\n                      \u2010resolved\n                      <jats:sup>1<\/jats:sup>\n                      H MRS and Prior Knowledge Fitting (ProFit).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>\n                      2D\n                      <jats:italic>J<\/jats:italic>\n                      \u2010resolved\n                      <jats:sup>1<\/jats:sup>\n                      H MRS spectra were acquired from the anterior cingulate cortex (ACC) and the parietal\u2010occipital cortex (POC) of 10 healthy subjects at a magnetic field strength of 2.9 Tesla. Amplitude correlation matrices were constructed for each subject and brain region to assess metabolite discriminability. ProFit\u2010estimated metabolite peak areas were normalized to a water reference signal, and intra\u2010 and inter\u2010subject reproducibility was evaluated.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Favorable between\u2010metabolite correlation coefficients (&lt;20%) were observed for a range of metabolites. Lower correlation coefficients between a given pair of metabolite estimates were consistently observed for POC metabolites. The group mean correlation coefficient existing between glutamate and glutamine was calculated as \u221218% and \u221213% for ACC and POC, respectively. Most ACC and POC metabolites showed intra\u2010 and inter\u2010subject CV values of &lt;15% and &lt;20%, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>\n                      The observed Glu and Gln signal discrimination makes these techniques suitable for investigating a variety of psychiatric disorders. Intra\u2010 and inter\u2010subject metabolite level reproducibility was comparable to the existing literature findings. These data serve as a valuable benchmark for assessing future modifications to 2D\n                      <jats:sup>1<\/jats:sup>\n                      H MRS data acquisition and ProFit analysis. J. Magn. Reson. Imaging 2013;37:642\u2013651. \u00a9 2012 Wiley Periodicals, Inc.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jmri.23848","type":"journal-article","created":{"date-parts":[[2012,10,11]],"date-time":"2012-10-11T07:19:15Z","timestamp":1349939955000},"page":"642-651","source":"Crossref","is-referenced-by-count":34,"title":["Two\u2010dimensional\n                    <i>J<\/i>\n                    \u2010resolved proton MR spectroscopy and prior knowledge fitting (ProFit) in the frontal and parietal lobes of healthy volunteers: Assessment of metabolite discrimination and general reproducibility"],"prefix":"10.1002","volume":"37","author":[{"given":"Andrew P.","family":"Prescot","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Perry 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