{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T01:27:40Z","timestamp":1784942860009,"version":"3.55.0"},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,2,25]],"date-time":"2013-02-25T00:00:00Z","timestamp":1361750400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:p>Cerebral toxoplasmosis is a frequent cause of focal brain lesions in the setting of immunodeficiency states, particularly acquired immune deficiency syndrome (AIDS), and magnetic resonance imaging (MRI) is an important diagnostic modality to differentiate toxoplasmosis from tuberculoma, and primary central nervous system lymphoma with diverse therapeutic implications. Several imaging patterns have been described in cerebral toxoplasmosis. The \u201cconcentric target sign\u201d is a recently described MRI sign on T2\u2010weighted imaging of cerebral toxoplasmosis that has concentric alternating zones of hypo\u2010 and hyperintensities. It is believed to be more specific than the well\u2010known \u201ceccentric target sign\u201d in the diagnosis of cerebral toxoplasmosis and hence more useful in differentiation from other focal brain lesions in the context of AIDS. The concentric target sign, seen in deep parenchymal lesions, is distinct from the surface\u2010based cortical \u201ceccentric\u201d target sign. The histopathological correlate of the latter has been recently described, but that of the concentric target sign is not known. In this study we describe the neuropathological correlate of this concentric target sign from the postmortem of a 40\u2010year\u2010old man with AIDS\u2010associated cerebral toxoplasmosis. The concentric alternating zones of hypo\/hyper\/iso\/intensities corresponded to zones of hemorrhage\/fibrin\u2010rich necrosis with edema\/coagulative compact necrosis\/inflammation with foamy histiocytes admixed with hemorrhage forming the outermost zone, respectively. The exclusive specificity of this sign in cerebral toxoplasmosis remains to be further elucidated. J. Magn. Reson. Imaging 2013;38:488\u2013495. \u00a9 2013 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/jmri.24036","type":"journal-article","created":{"date-parts":[[2013,2,25]],"date-time":"2013-02-25T16:24:54Z","timestamp":1361809494000},"page":"488-495","source":"Crossref","is-referenced-by-count":62,"title":["Neuropathological correlate of the \u201cconcentric target sign\u201d in MRI of HIV\u2010associated cerebral toxoplasmosis"],"prefix":"10.1002","volume":"38","author":[{"given":"Anita","family":"Mahadevan","sequence":"first","affiliation":[{"name":"Department of Neuropathology National Institute of Mental Health &amp; Neurosciences Bangalore India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arvinda Hanumantapura","family":"Ramalingaiah","sequence":"additional","affiliation":[{"name":"Department of Neuroimaging &amp; Interventional Radiology National Institute of Mental Health &amp; Neurosciences Bangalore India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satishchandra","family":"Parthasarathy","sequence":"additional","affiliation":[{"name":"Department of Neurology National Institute of Mental Health &amp; Neurosciences Bangalore India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Avindra","family":"Nath","sequence":"additional","affiliation":[{"name":"Section of Infections of the Nervous System NINDS National Institutes of Health Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Udaykumar","family":"Ranga","sequence":"additional","affiliation":[{"name":"HIV\u2010AIDS Laboratory, Molecular Biology and Genetics Unit Jawaharlal Nehru Centre for Advanced Scientific Research Bangalore India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shankar Susarla","family":"Krishna","sequence":"additional","affiliation":[{"name":"Department of Neuropathology National Institute of Mental Health &amp; Neurosciences Bangalore India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,2,25]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-120-11-199406010-00007"},{"key":"e_1_2_5_3_1","first-page":"615","article-title":"Neuroimaging\u2014autopsy correlations in AIDS","volume":"7","author":"Smirniotopoulos JG","year":"1997","journal-title":"Neuroimaging Clin N Am"},{"key":"e_1_2_5_4_1","first-page":"14","article-title":"Profile of neurological disorders associated with HIV\/AIDS from Bangalore, South India (1989\u20131996)","volume":"111","author":"Satishchandra P","year":"2000","journal-title":"Indian J Med Res"},{"key":"e_1_2_5_5_1","first-page":"468","article-title":"Neuropathology of HIV\/AIDS with an overview of the Indian scene","volume":"121","author":"Shankar SK","year":"2005","journal-title":"Indian J Med Res"},{"key":"e_1_2_5_6_1","first-page":"171","article-title":"Neuroimaging of AIDS. 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