{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T20:48:25Z","timestamp":1762375705238},"reference-count":42,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,3,5]],"date-time":"2013-03-05T00:00:00Z","timestamp":1362441600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2013,11]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p>To explore whether diffusion\u2010weighted imaging (DWI) can localize specific segments of primary motor areas in children with Sturge\u2010Weber syndrome (SWS), this study investigated the corticospinal tract (CST) between precentral gyrus (PCG) and posterior limb of internal capsule (PIC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>DWI was performed on 32 healthy children and seven children with unilateral SWS affecting the sensorimotor area variably. A hierarchical dendrogram was applied to find PCG\u2010segments uniquely connected to PIC\u2010segments. The resulting PCG\u2010clusters were used to image primary motor pathways in DWI and find metabolic abnormalities of primary motor areas in positron emission tomography (PET) scans.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In healthy children, five PCG\u2010clusters were found to have unique CST courses, corresponding to CST segments of mouth\/lip, fingers, and leg\/ankle primary motor areas determined by functional magnetic resonance imaging (fMRI). In children with SWS, reduced streamlines in these PCG clusters were highly correlated with glucose\u2010hypometabolism on PET (R<jats:sup>2<\/jats:sup> = 0.2312, <jats:italic>P<\/jats:italic> = 0.0032). Impaired CST segment corresponding to finger movements correlated with severity of hand motor deficit.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The presented method can detect impaired CST segments corresponding to specific motor functions in young children who cannot cooperate for fMRI. This approach can be clinically useful for a noninvasive presurgical evaluation of cortical motor areas in such children. J. Magn. Reson. Imaging 2013;38:1152\u20131161. \u00a9 2013 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.24076","type":"journal-article","created":{"date-parts":[[2013,3,5]],"date-time":"2013-03-05T18:16:38Z","timestamp":1362507398000},"page":"1152-1161","source":"Crossref","is-referenced-by-count":10,"title":["Localization of function\u2010specific segments of the primary motor pathway in children with Sturge\u2010Weber syndrome: A multimodal imaging analysis"],"prefix":"10.1002","volume":"38","author":[{"given":"Jeong\u2010Won","family":"Jeong","sequence":"first","affiliation":[{"name":"Carman and Ann Adams Department of Pediatrics Wayne State University School of Medicine Detroit Michigan USA"},{"name":"Department of Neurology Wayne State University School of Medicine Detroit Michigan USA"},{"name":"Translational Imaging Laboratory Children's Hospital of Michigan Detroit Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harry T.","family":"Chugani","sequence":"additional","affiliation":[{"name":"Carman and Ann Adams Department of Pediatrics Wayne State University School of Medicine Detroit Michigan USA"},{"name":"Department of Neurology Wayne State University School of Medicine Detroit Michigan USA"},{"name":"Translational Imaging Laboratory Children's Hospital of Michigan Detroit Michigan USA"},{"name":"Department of Radiology Wayne State University School of Medicine Detroit Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Csaba","family":"Juh\u00e1sz","sequence":"additional","affiliation":[{"name":"Carman and Ann Adams Department of Pediatrics Wayne State University School of Medicine Detroit Michigan USA"},{"name":"Department of Neurology Wayne State University School of Medicine Detroit Michigan USA"},{"name":"Translational Imaging Laboratory Children's Hospital of Michigan Detroit Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,3,5]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"19","volume-title":"Sturge\u2010Weber syndrome. 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