{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T00:58:04Z","timestamp":1786323484417,"version":"build-2736575974"},"reference-count":18,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,5,23]],"date-time":"2013-05-23T00:00:00Z","timestamp":1369267200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p>To investigate changes in image quality and observer variance between rest and higher\u2010dose dobutamine stress MR imaging (DS\u2010MR) in tetralogy of Fallot (TOF) patients and in a group of normal healthy volunteers using both axial and short axis orientation for cardiac volumetric assessment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Eighteen adult patients (age 34 \u00b1 13) with TOF and severe pulmonary regurgitation and 10 healthy volunteers underwent ventricular MR volumetry at baseline and during dobutamine infusion of 10 \u03bcg\/kg\/min and 20 \u03bcg\/kg\/min. Inter\u2010observer and intra\u2010observer agreement was calculated by coefficient of variance (COV).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Inter\u2010observer comparison showed good agreement for left ventricle (LV) and right ventricle (RV) end\u2010diastolic volumes at rest and both stress levels in TOF patients (axial geometry) and in normal volunteers (short axis). During dobutamine stress, the COV in TOF patients increased for LV end\u2010systolic volume (LV\u2010ESV) with each level, suggesting less agreement between observers. In contrast, RV\u2010ESV was much more comparable with a COV &lt; 10 at each condition. All volumetric measurements in normal volunteers showed good inter\u2010observer agreement. Excellent intra\u2010observer agreement could be seen for all volumetric parameters with COV levels below 7.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Volumetric assessment during DS\u2010MR shows excellent inter\u2010observer agreement, except for LV\u2010ESV in the TOF patients at higher doses of dobutamine. The axial geometry appears to be reproducible for assessment of RV parameters, and could be considered superior to short axis imaging in patients with repaired TOF. J. Magn. Reson. Imaging 2013;38:1356\u20131361. \u00a9 2013 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.24103","type":"journal-article","created":{"date-parts":[[2013,5,23]],"date-time":"2013-05-23T20:00:17Z","timestamp":1369339217000},"page":"1356-1361","source":"Crossref","is-referenced-by-count":2,"title":["Higher dose dobutamine stress MR imaging in repaired tetralogy of fallot: Observer variance of volumetric assessment compared with normal volunteers"],"prefix":"10.1002","volume":"38","author":[{"given":"Victoria","family":"Parish","sequence":"first","affiliation":[{"name":"King's College London BHF Centre Division of Imaging Sciences NIHR Biomedical Research Centre at Guy's and St Thomas' NHS Foundation Trust London UK"},{"name":"Adult Congenital Heart Disease Service Guy's and St Thomas' NHS Foundation Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Israel","family":"Valverde","sequence":"additional","affiliation":[{"name":"King's College London BHF Centre Division of Imaging Sciences NIHR Biomedical Research Centre at Guy's and St Thomas' NHS Foundation Trust London UK"},{"name":"Evelina Children Hospital Guy's and St Thomas' NHS Foundation Trust, Department of Pediatric Cardiology London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shelby","family":"Kutty","sequence":"additional","affiliation":[{"name":"University of Nebraska College of Medicine Division of Pediatric Cardiology \u2013 Cardiac Imaging Children's Hospital and Medical Center Omaha Nebraska USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Head","sequence":"additional","affiliation":[{"name":"Adult Congenital Heart Disease Service Guy's and St Thomas' NHS Foundation Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerald F.","family":"Greil","sequence":"additional","affiliation":[{"name":"King's College London BHF Centre Division of Imaging Sciences NIHR 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