{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:49:44Z","timestamp":1786978184078,"version":"build-2736575974"},"reference-count":65,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,4,15]],"date-time":"2013-04-15T00:00:00Z","timestamp":1365984000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>\n                      To compare hyperpolarized helium\u20103 (\n                      <jats:sup>3<\/jats:sup>\n                      He) and xenon\u2010129 (\n                      <jats:sup>129<\/jats:sup>\n                      Xe) MRI in asthmatics before and after salbutamol inhalation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      Seven asthmatics provided written informed consent and underwent spirometry, plethysmography, and MRI before and after salbutamol inhalation.\n                      <jats:sup>3<\/jats:sup>\n                      He and\n                      <jats:sup>129<\/jats:sup>\n                      Xe ventilation defect percent (VDP) and ventilation coefficient of variation (COV) were measured. To characterize the airways spatially related to ventilation defects, wall area percent (WA%) and lumen area (LA) were evaluated for two subjects who had thoracic x\u2010ray computed tomography (CT) acquired 1 year before MRI.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Before salbutamol inhalation,\n                      <jats:sup>129<\/jats:sup>\n                      Xe VDP (8 \u00b1 5%) was significantly greater than\n                      <jats:sup>3<\/jats:sup>\n                      He VDP (6 \u00b1 5%,\n                      <jats:italic>P<\/jats:italic>\n                      = 0.003). Post\u2010salbutamol, there was a significant improvement in both\n                      <jats:sup>129<\/jats:sup>\n                      Xe (5 \u00b1 4%,\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.0001) and\n                      <jats:sup>3<\/jats:sup>\n                      He (4 \u00b1 3%,\n                      <jats:italic>P<\/jats:italic>\n                      = 0.001) VDP, and the improvement in\n                      <jats:sup>129<\/jats:sup>\n                      Xe VDP was significantly greater (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.008).\n                      <jats:sup>129<\/jats:sup>\n                      Xe MRI COV (Pre: 0.309 \u00b1 0.028, Post: 0.296 \u00b1 0.036) was significantly greater than\n                      <jats:sup>3<\/jats:sup>\n                      He MRI COV (Pre: 0.282 \u00b1 0.018, Post: 0.269 \u00b1 0.024), pre\u2010 (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.0001) and post\u2010salbutamol (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.0001) and the decrease in COV post\u2010salbutamol was significant (\n                      <jats:sup>129<\/jats:sup>\n                      Xe,\n                      <jats:italic>P<\/jats:italic>\n                      = 0.002;\n                      <jats:sup>3<\/jats:sup>\n                      He,\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.0001). For a single asthmatic, a sub\u2010segmental\n                      <jats:sup>129<\/jats:sup>\n                      Xe MRI ventilation defect that was visible only before salbutamol inhalation but not visible using\n                      <jats:sup>3<\/jats:sup>\n                      He MRI was spatially related to a remodeled fourth generation sub\u2010segmental airway (WA% = 78%, LA = 2.9 mm\n                      <jats:sup>2<\/jats:sup>\n                      ).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      In asthma, hyperpolarized\n                      <jats:sup>129<\/jats:sup>\n                      Xe MRI may help reveal ventilation abnormalities before bronchodilation that are not observed using hyperpolarized\n                      <jats:sup>3<\/jats:sup>\n                      He MRI. J. Magn. Reson. Imaging 2013;38:1521\u20131530. \u00a9 2013 Wiley Periodicals, Inc.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jmri.24111","type":"journal-article","created":{"date-parts":[[2013,4,15]],"date-time":"2013-04-15T16:36:52Z","timestamp":1366043812000},"page":"1521-1530","source":"Crossref","is-referenced-by-count":153,"title":["Hyperpolarized\n                    <sup>3<\/sup>\n                    He and\n                    <sup>129<\/sup>\n                    Xe MRI: Differences in asthma before bronchodilation"],"prefix":"10.1002","volume":"38","author":[{"given":"Sarah","family":"Svenningsen","sequence":"first","affiliation":[{"name":"Imaging Research Laboratories Robarts Research Institute London Canada"},{"name":"Department of Medical Biophysics The University of Western Ontario London Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miranda","family":"Kirby","sequence":"additional","affiliation":[{"name":"Imaging Research 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