{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T16:10:20Z","timestamp":1746115820158,"version":"3.40.4"},"reference-count":63,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,7,15]],"date-time":"2013-07-15T00:00:00Z","timestamp":1373846400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p>To show the gray matter volumes in the default mode network (DMN) using the atlas\u2010based method and to evaluate age\u2010related volume change in the DMN region. Estimation of gray matter volumes is interesting research because previous reports showed an association with gray matter volume (GMV) and diseases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>We focused on five nodes of the DMN (posterior cingulate, precuneus, lateral temporal cortex [LTC], medial prefrontal cortex, and inferior parietal lobule). In all, 1122 healthy adults were included in the present study. T1\u2010weighted magnetic resonance (MR) images were obtained using a 3T\u2010MR scanner. To investigate GMV in the DMN, segmented gray matter images were measured by the atlas\u2010based method, using Statistical Parametric Mapping 5. Volumes were expressed using three different methods: region of interest (ROI)\u2010volume (mL), the volume itself; ROI\u2010TIV (%), as a percentage of total intracranial volume (individual difference of head size is corrected); and ROI\u2010GMV (%), as a percentage of gray matter volume (individual difference of atrophy speed for aging is corrected).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Negative correlations between measurement values on ROI and age were observed in all five ROIs of the DMN region by two measures of volume (ROI\u2010volume (mL) and ROI\u2010TIV (%)), in both genders. In contrast, positive correlations between measurement values on ROI and age were observed in the posterior cingulate and LTC with ROI\u2010GMV (%), in both genders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The present study is the first report about volume change in the DMN that includes age\u2010related effects. J. Magn. Reson. 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