{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T10:18:19Z","timestamp":1792664299047,"version":"4.5.0"},"reference-count":52,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,4,15]],"date-time":"2013-04-15T00:00:00Z","timestamp":1365984000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p>To quantify spatial and temporal inflammation\u2010induced changes in vascular permeability and macrophage infiltration in guinea\u2010pig (GP) cochlea using MRI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>GPs were injected with lipopolysaccharide (LPS) to induce cochlear inflammation. One group was injected with a gadolinium based contrast agent (GBCA) and dynamic contrast enhanced (DCE)\u2010MRI was performed at 4, 7, and 10 days after LPS treatment. A two\u2010compartment pharmacokinetic model was used to determine the apparent rate constant of GBCA extravasation (K<jats:sup>trans<\/jats:sup>). A second group was injected with ultrasmall superparamagnetic iron oxide particles (USPIOs) and studied at 2, 3, and 7 days after LPS treatment to detect tissue USPIO uptake and correlate with histology. For both groups, control GPs were scanned similarly.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The signal enhancement increased substantially and more rapidly at day 4 in LPS\u2010treated than in control cochlea shortly following GBCA injection. K<jats:sup>trans<\/jats:sup> of LPS\u2010treated cochlea was maximum on day 4 at 0.0218\u2009\u00b1\u20090.0032 min<jats:sup>\u22121<\/jats:sup> and then decreased to control level at 0.0036\u2009\u00b1\u20090.0004 min<jats:sup>\u22121<\/jats:sup> by day 10. In the second group, the relative signal intensity and T<jats:sub>2<\/jats:sub> in cochlear perilymphatic spaces on day 2 decreased, on average, by 54% and 45%, respectively, compared with baseline and then remained under control levels by day 7. This suggests the infiltration of inflammatory cells, although unconfirmed by histology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This provides the first measurement of cochlear vascular permeability using MRI and a quantitative evaluation of the development of cochlear inflammation. MRI holds considerable potential for the assessment of disease processes such as clinical diagnosis of conditions such as labyrinthitis. J. Magn. Reson. 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