{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T09:34:49Z","timestamp":1778319289050,"version":"3.51.4"},"reference-count":40,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,5,30]],"date-time":"2013-05-30T00:00:00Z","timestamp":1369872000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p>To develop a framework for quantitative detection of between\u2010group textural differences in ultrahigh field T<jats:sub>2<\/jats:sub>*\u2010weighted MR images of the brain.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>MR images were acquired using a three\u2010dimensional (3D) T<jats:sub>2<\/jats:sub>*\u2010weighted gradient echo sequence on a 7 Tesla MRI system. The phase images were high\u2010pass filtered to remove phase wraps. Thirteen textural features were computed for both the magnitude and phase images of a region of interest based on 3D Gray\u2010Level Co\u2010occurrence Matrix, and subsequently evaluated to detect between\u2010group differences using a Mann\u2010Whitney U\u2010test. We applied the framework to study textural differences in subcortical structures between premanifest Huntington's disease (HD), manifest HD patients, and controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In premanifest HD, four phase\u2010based features showed a difference in the caudate nucleus. In manifest HD, 7 magnitude\u2010based features showed a difference in the pallidum, 6 phase\u2010based features in the caudate nucleus, and 10 phase\u2010based features in the putamen. After multiple comparison correction, significant differences were shown in the putamen in manifest HD by two phase\u2010based features (both adjusted <jats:italic>P<\/jats:italic> values\u2009=\u20090.04).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study provides the first evidence of textural heterogeneity of subcortical structures in HD. Texture analysis of ultrahigh field T<jats:sub>2<\/jats:sub>*\u2010weighted MR images can be useful for noninvasive monitoring of neurodegenerative diseases. <jats:bold>J. Magn. Reson. Imaging 2014;39:633\u2013640<\/jats:bold>. \u00a9 <jats:bold>2013 Wiley Periodicals, Inc<\/jats:bold>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.24199","type":"journal-article","created":{"date-parts":[[2013,5,30]],"date-time":"2013-05-30T17:36:51Z","timestamp":1369935411000},"page":"633-640","source":"Crossref","is-referenced-by-count":11,"title":["Texture analysis of ultrahigh field T<sub>2<\/sub>*\u2010weighted MR images of the brain: Application to Huntington's disease"],"prefix":"10.1002","volume":"39","author":[{"given":"Nhat Trung","family":"Doan","sequence":"first","affiliation":[{"name":"Division of Image Processing (LKEB) Department of Radiology Leiden University Medical Center Leiden the Netherlands."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon J.A.","family":"van den Bogaard","sequence":"additional","affiliation":[{"name":"Department of Neurology Leiden University Medical Center Leiden the Netherlands."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eve M.","family":"Dumas","sequence":"additional","affiliation":[{"name":"Department of Neurology Leiden University Medical Center Leiden the Netherlands."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew G.","family":"Webb","sequence":"additional","affiliation":[{"name":"CJ Gorter Center for High\u2010field MRI Department of Radiology Leiden University Medical Center Leiden the Netherlands."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark A.","family":"van Buchem","sequence":"additional","affiliation":[{"name":"CJ Gorter Center for High\u2010field MRI Department of Radiology Leiden University Medical Center Leiden the Netherlands."},{"name":"Department of Radiology Leiden University Medical Center Leiden the Netherlands."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raymund 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