{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T19:48:56Z","timestamp":1790711336768,"version":"4.1.0"},"reference-count":41,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,11,20]],"date-time":"2013-11-20T00:00:00Z","timestamp":1384905600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p>To employ the stretched exponential and diffusional kurtosis models to study the non\u2010Gaussian behavior of diffusion\u2010related signal decay of the liver in an animal model of hepatic fibrosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>High b\u2010value diffusion imaging data (up to 3500 s\/mm<jats:sup>2<\/jats:sup>) of ex vivo murine liver specimens was acquired using a 9.4 T MRI scanner. A simple monoexponential model as well as the stretched exponential and diffusional kurtosis models were employed to analyze the diffusion data, the results of which were correlated with liver histopathology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Strong correlations between histopathological assessments of hepatic fibrosis and parameters derived from the stretched exponential and diffusional kurtosis models were found. Using Akaike's Information Criterion (AIC) analyses, the kurtosis model was found to result in an improved fit of the high b\u2010value diffusion data when compared to both the monoexponential and stretched exponential models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The use of diffusional kurtosis or stretched exponential models, applied to the characterization of the non\u2010Gaussian behavior of the molecular diffusion of liver exhibited over an extended b\u2010factor range, affords the potential for an increased capability of magnetic resonance imaging (MRI) in the characterization of chronic liver disease. <jats:bold>J. Magn. Reson. Imaging 2014;39:827\u2013834.<\/jats:bold> \u00a9 <jats:bold>2013 Wiley Periodicals, Inc<\/jats:bold>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.24234","type":"journal-article","created":{"date-parts":[[2013,11,20]],"date-time":"2013-11-20T18:06:13Z","timestamp":1384970773000},"page":"827-834","source":"Crossref","is-referenced-by-count":62,"title":["Characterizing non\u2010gaussian, high b\u2010value diffusion in liver fibrosis: Stretched exponential and diffusional kurtosis modeling"],"prefix":"10.1002","volume":"39","author":[{"given":"Stephan W.","family":"Anderson","sequence":"first","affiliation":[{"name":"Boston University Medical Center Department of Radiology Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Barry","sequence":"additional","affiliation":[{"name":"Boston University Medical Center Department of Radiology Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Soto","sequence":"additional","affiliation":[{"name":"Boston University Medical Center Department of Radiology Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Al","family":"Ozonoff","sequence":"additional","affiliation":[{"name":"Design and Analysis Core Clinical Research Center, Children's Hospital Boston Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"O'Brien","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Boston University School of Medicine Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hernan","family":"Jara","sequence":"additional","affiliation":[{"name":"Boston University Medical Center Department of Radiology Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,11,20]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0221-0363(04)97582-8"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.20344"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.07.2086"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-011-2295-z"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.10.4580"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.09.2436"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.22081"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2493080080"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/1522-2594(200012)44:6<852::AID-MRM5>3.0.CO;2-A"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.10183"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.20508"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.21563"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mri.2005.12.008"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mri.2008.07.008"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.22507"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.1544"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.10581"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.22070"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.1441"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.1518"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mri.2012.05.010"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2007.061133"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1017\/CBO9780511802843"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.180.1.1800047"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1109\/TAC.1974.1100705"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.23205"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.22807"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmr.2011.12.023"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.20286"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2261011904"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.acra.2011.09.009"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.23519"},{"key":"e_1_2_5_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.1020"},{"key":"e_1_2_5_35_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.219.3.r01jn02842"},{"key":"e_1_2_5_36_1","article-title":"Distortion free high resolution in vivo whole brain diffusion tensor image on 7.0T MRI. 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