{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T02:18:52Z","timestamp":1773800332478,"version":"3.50.1"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,10,29]],"date-time":"2013-10-29T00:00:00Z","timestamp":1383004800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2014,7]]},"abstract":"Purpose<\/jats:title>To prospectively evaluate the accuracy of diffusion\u2010weighted (DW) magnetic resonance (MR) imaging with background signal suppression (MR\u2010DWIBS) for detecting mediastinal lymph node metastasis of nonsmall\u2010cell lung cancer (NSCLC).<\/jats:p><\/jats:sec>Materials and Methods<\/jats:title>MR\u2010DWIBS was performed in 42 consecutive patients (27 men, 15 women; age range, 42\u201378 years; median age, 55 years) with histologically proven NSCLC. The visualization rate of metastatic lymph node (MLN) and benign lymph node (BLN) of enlarged lymph nodes (ELN) and normal\u2010sized lymph nodes (NLN) was compared by using a chi\u2010square test or Fisher's exact test on a per\u2010nodal basis. Apparent diffusion coefficient (ADC) of MLN and BLN was measured and compared by using two\u2010tailed unpaired Student's t<\/jats:italic>\u2010test. Receiver operating characteristic (ROC) analysis was used to assess the overall diagnostic accuracy of ADC for ELN and NLN. The optimal cutoff value was determined and the sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy was calculated.<\/jats:p><\/jats:sec>Results<\/jats:title>Thirty\u2010five out of 119 lymph resected nodes were confirmed to be metastatic by histologic examination. The visualization rate of MLN was significantly higher than that of BLN for ELN (P<\/jats:italic>\u2009<\u20090.001) and for NLN (\u03c72<\/jats:sup><\/jats:italic>\u2009=\u20097.506, P<\/jats:italic>\u2009=\u20090.006). For both ELN and NLN, ADC of MLN was significantly lower than that of BLN (t<\/jats:italic>\u2009=\u2009\u22125.380, P<\/jats:italic>\u2009<\u20090.001 and t<\/jats:italic>\u2009=\u2009\u22126.435, P<\/jats:italic>\u2009<\u20090.001). ADC was significant for detection of MLN for both ELN (Az<\/jats:italic>\u2009=\u20090.975, P<\/jats:italic>\u2009<\u20090.001) and NLN (Az<\/jats:italic>\u2009=\u20090.919, P<\/jats:italic>\u2009<\u20090.001). For NLN, the optimal cutoff value of ADC was 2.04 mm2<\/jats:sup>\/s, where the sensitivity, specificity, PPV, NPV, and accuracy were 75.0%, 90.9%, 66.7%, 93.8%, and 87.8%, respectively.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>MR\u2010DWIBS may be clinically useful to visually detect mediastinal lymph nodes and ADC measurement can aid in malignant node discrimination. J. Magn. Reson. Imaging 2014;40:200\u2013205<\/jats:bold>. \u00a9 2013 Wiley Periodicals, Inc<\/jats:bold>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.24343","type":"journal-article","created":{"date-parts":[[2013,10,29]],"date-time":"2013-10-29T15:07:56Z","timestamp":1383059276000},"page":"200-205","source":"Crossref","is-referenced-by-count":26,"title":["Accuracy of diffusion\u2010weighted (DW) MRI with background signal suppression (MR\u2010DWIBS) in diagnosis of mediastinal lymph node metastasis of nonsmall\u2010cell lung cancer (NSCLC)"],"prefix":"10.1002","volume":"40","author":[{"given":"Liang","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Radiology Shandong Cancer Hospital Shandong Academy of Medical Sciences Ji'nan P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiakai","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Special Examination Shandong Provincial Chest Hospital Ji'nan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuhui","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Radiology Shandong Cancer Hospital Shandong Academy of Medical Sciences Ji'nan P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chuanfu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Radiology Qilu Hospital of Shandong University. Ji'nan P.R. 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