{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,7]],"date-time":"2023-10-07T06:18:46Z","timestamp":1696659526460},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,10,17]],"date-time":"2013-10-17T00:00:00Z","timestamp":1381968000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2014,7]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p>To demonstrate the feasibility that the pseudo\u2010continuous transfer insensitive labeling technique (pTILT) sequence can be modified to achieve regional perfusion imaging by either vessel\u2010encoded or vessel\u2010selective pTILT, similar to the regional perfusion imaging sequences using pseudo\u2010continuous arterial spin labeling (pCASL).<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Static phantom experiments were carried out to investigate the selectivity and efficiency of region\u2010specific labeling by pTILT. The ability of the modified pTILT sequences to separate perfusion territories was also examined at two levels of the arterial tree on four healthy subjects: (i) the left and right internal carotid arteries (ICAs) and (ii) individual vascular territories of arteries above the circle of Willis (anterior cerebral artery [ACA], left and right middle cerebral arteries [MCAs]).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the phantom study, compared with non\u2013region\u2010specific pTILT, a labeling efficiency of 0.92 and 0.88 was measured at the target vessels using vessel\u2010encoded and vessel\u2010selective pTILT, respectively. In human studies, the perfusion territories of ACA, left and right MCA branches with estimated CBF of 74.5 \u00b1 26.1, 65.9 \u00b1 7.2, and 72.3 \u00b1 14.5 mL\/100 g\/min, respectively, as well as more general left\/right end territories (76.8 \u00b1 12.7 and 72.8 \u00b1 7.2 mL\/100 g\/min), were clearly delineated by the modified pTILT sequences for regional perfusion imaging.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Two regional perfusion imaging modules (vessel\u2010encoded and vessel\u2010selective) used in pCASL can also be adapted into the pTILT sequence, and our results confirmed that the region\u2010specific pTILT sequence is capable of regional perfusion imaging to separate perfusion territories of major cerebral arteries. <jats:bold>J. Magn. Reson. Imaging 2014;40:192\u2013199<\/jats:bold>. \u00a9 <jats:bold>2013 Wiley Periodicals, Inc<\/jats:bold>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.24346","type":"journal-article","created":{"date-parts":[[2013,10,17]],"date-time":"2013-10-17T21:02:40Z","timestamp":1382043760000},"page":"192-199","source":"Crossref","is-referenced-by-count":0,"title":["Regional perfusion imaging using pTILT"],"prefix":"10.1002","volume":"40","author":[{"given":"Cheng","family":"Ouyang","sequence":"first","affiliation":[{"name":"Toshiba Medical Research Institute USA, Inc. Vernon Hills Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bradley P.","family":"Sutton","sequence":"additional","affiliation":[{"name":"Bioengineering Department University of Illinois at Urbana\u2010Champaign Urbana Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,10,17]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1227\/01.NEU.0000170563.70822.10"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2422060179"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A1351"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000120312.26163.EC"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1522-2594(199906)41:6<1093::AID-MRM4>3.0.CO;2-0"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.10438"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.10475"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.20475"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.21790"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.21293"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.22363"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.22451"},{"key":"e_1_2_5_14_1","unstructured":"OuyangC SuttonBP.Pushing transfer Insensitive labeling technique (TILT) from pulsed arterial spin labeling to pulsed\u2010continuous arterial spin labeling. 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