{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T04:23:24Z","timestamp":1782275004498,"version":"3.54.5"},"reference-count":34,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,11,4]],"date-time":"2013-11-04T00:00:00Z","timestamp":1383523200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p>To determine if patients with certain bicuspid aortic valve (BAV) phenotypes are predisposed to particular morphological abnormalities of the thoracic aorta.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>One hundred ninety\u2010two patients with BAV who underwent magnetic resonance angiography between January 2007 and July 2010 were retrospectively identified. Aortic morphology was examined through measurements of aortic size index at nine levels along the thoracic aorta, three\u2010dimensional volume of the ascending aorta, vessel asymmetry, and assessment of aortic root morphology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We found 140 patients (73%) with right and left coronary cusps (R\u2010L) fusion, 46 patients (24%) with R\u2010N fusion, and 6 patients (3%) with left and noncoronary cusps (L\u2010N) fusion. Mean aortic volume in the proximal ascending aorta was significantly greater in R\u2010L patients (0.93 versus 0.60 cm<jats:sup>3<\/jats:sup>\/m<jats:sup>2<\/jats:sup>; <jats:italic>P<\/jats:italic> &lt; 0.01). R\u2010N patients possessed greater aortic size index at the distal ascending aorta and proximal aortic arch, and were also significantly more likely to have Type 2 patterns of aortic dilatation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our results suggest that BAV with R\u2010L fusion is associated with increased dimensions of the aortic root, while BAV with R\u2010N fusion is associated with increased dimensions of the distal ascending aorta and proximal arch. Our findings illustrate the morphological heterogeneity that exists among BAV phenotypes. <jats:bold>J. Magn. Reson. Imaging 2014;40:294\u2013300<\/jats:bold>. \u00a9 <jats:bold>2013 Wiley Periodicals, Inc<\/jats:bold>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.24376","type":"journal-article","created":{"date-parts":[[2013,11,4]],"date-time":"2013-11-04T15:30:29Z","timestamp":1383579029000},"page":"294-300","source":"Crossref","is-referenced-by-count":11,"title":["Association between leaflet fusion pattern and thoracic aorta morphology in patients with bicuspid aortic valve"],"prefix":"10.1002","volume":"40","author":[{"given":"Bryce A.","family":"Merritt","sequence":"first","affiliation":[{"name":"Northwestern University Feinberg School of Medicine, Department of Radiology Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Turin","sequence":"additional","affiliation":[{"name":"Northwestern University Feinberg School of Medicine, Department of Radiology Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Markl","sequence":"additional","affiliation":[{"name":"Northwestern University Feinberg School of Medicine, Department of Radiology Chicago Illinois USA"},{"name":"Department of Biomedical Engineering Northwestern University Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. Chris","family":"Malaisrie","sequence":"additional","affiliation":[{"name":"Northwestern University Feinberg School of Medicine, Division of Cardiac Surgery Chicago Illinois USA"},{"name":"Bluhm Cardiovascular Institute at Northwestern Memorial Hospital Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick M.","family":"McCarthy","sequence":"additional","affiliation":[{"name":"Northwestern University Feinberg School of Medicine, Division of Cardiac Surgery Chicago Illinois USA"},{"name":"Bluhm Cardiovascular Institute at Northwestern Memorial Hospital Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James C.","family":"Carr","sequence":"additional","affiliation":[{"name":"Northwestern University Feinberg School of Medicine, Department of Radiology Chicago Illinois USA"},{"name":"Bluhm Cardiovascular Institute at Northwestern Memorial Hospital Chicago Illinois USA"},{"name":"Northwestern University Feinberg 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