{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T20:24:04Z","timestamp":1787775844948,"version":"build-2784847793"},"reference-count":41,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,11,8]],"date-time":"2013-11-08T00:00:00Z","timestamp":1383868800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p>To compare cerebral blood flow (CBF) values measured using magnetic resonance imaging (MRI) arterial spin labeling (ASL) with those obtained with [<jats:sup>15<\/jats:sup>O]H<jats:sub>2<\/jats:sub>O positron emission tomography (PET), the gold standard for measuring CBF in vivo.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Data were collected in 11 healthy men and in 20 age\u2010 and body mass index (BMI)\u2010matched type 1 diabetic men. Pseudo\u2010continuous ASL (PCASL) data were acquired at 3 T and [<jats:sup>15<\/jats:sup>O]H<jats:sub>2<\/jats:sub>O PET scans were acquired using a high\u2010resolution PET scanner. Input functions were obtained using on\u2010line arterial blood sampling. Whole brain and regional CBF values were compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>For both modalities, whole brain CBF was similar in both subject groups. In groups combined, average whole brain CBF was 0.30 \u00b1 0.05 mL\u00b7cm<jats:sup>\u22123<\/jats:sup>\u00b7min<jats:sup>\u22121<\/jats:sup> for [<jats:sup>15<\/jats:sup>O]H<jats:sub>2<\/jats:sub>O PET and 0.34 \u00b1 0.05 mL\u00b7cm<jats:sup>\u22123<\/jats:sup>\u00b7min<jats:sup>\u22121<\/jats:sup> for ASL MRI (<jats:italic>P<\/jats:italic> &lt; 0.01). A significant correlation between methods was observed for whole brain, gray and white matter. In 12 out of 33 brain regions a significant difference between methods was observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>PCASL provides CBF values that correlate with [<jats:sup>15<\/jats:sup>O]H<jats:sub>2<\/jats:sub>O PET\u2010derived values, but is less accurate. PCASL may be an attractive alternative when absolute quantification is not needed.<jats:bold>J. Magn. Reson. Imaging 2014;40:1300\u20131309<\/jats:bold>. \u00a9 <jats:bold>2013 Wiley Periodicals, Inc<\/jats:bold>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.24484","type":"journal-article","created":{"date-parts":[[2013,11,8]],"date-time":"2013-11-08T15:26:41Z","timestamp":1383924401000},"page":"1300-1309","source":"Crossref","is-referenced-by-count":36,"title":["Quantification of cerebral blood flow in healthy volunteers and type 1 diabetic patients: Comparison of MRI arterial spin labeling and [<sup>15<\/sup>O]H<sub>2<\/sub>O positron emission tomography (PET)"],"prefix":"10.1002","volume":"40","author":[{"given":"Larissa W.","family":"van Golen","sequence":"first","affiliation":[{"name":"Diabetes Center\/ Department of Internal Medicine VU University Medical Center Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joost P.A.","family":"Kuijer","sequence":"additional","affiliation":[{"name":"Department of Physics and Medical Technology, Neuroscience 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