{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T06:20:10Z","timestamp":1780381210824,"version":"3.54.1"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,11,22]],"date-time":"2013-11-22T00:00:00Z","timestamp":1385078400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p>To compare the MR findings including diffusion\u2010weighted imaging (DWI) between symptomatic and asymptomatic patients with autoimmune pancreatitis (AIP) and to determine whether DWI can be used as an objective biomarker for symptomatic AIP, which is considered an indication for steroid therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>This retrospective study was approved by our institutional review board. MRI scans from 37 patients with AIP (symptomatic, n\u2009=\u200919; asymptomatic, n\u2009=\u200918) were retrospectively evaluated. The imaging studies were performed on a 1.5 Tesla scanner and assessed for parenchymal enlargement, narrowing of the main pancreatic duct, hypointensity on fat\u2010suppressed T1\u2010weighted images (FS\u2010T1WI), a capsule\u2010like rim, extrapancreatic lesions, and hyperintensity on DWI. The findings were compared by univariate and multivariate logistic regression analysis. Apparent diffusion coefficient (ADC) values were also calculated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Multivariate analysis showed that hyperintensity on DWI were most significantly associated with the symptoms of AIP (odds ratio\u2009=\u200928.2; <jats:italic>P<\/jats:italic>\u2009=\u20090.003). Interobserver agreement for DWI was also high. The ADC values were significantly lower in symptomatic than in asymptomatic patients (0.94\u2009\u00b1\u20090.17 versus 1.16\u2009\u00b1\u20090.16 \u00d7 10<jats:sup>\u22123<\/jats:sup> mm<jats:sup>2<\/jats:sup>\/s, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). Receiver operating characteristic curve analysis of the ADC values to differentiate between symptomatic and asymptomatic patients showed that sensitivity was 68.4%, specificity 83.3%, and AUC 0.74.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Signal intensity on DWI and ADC value were well correlated with the active symptoms of AIP patients. DWI may be useful as an objective biomarker for determining the indication for steroid therapy. <jats:bold>J. Magn. Reson. Imaging 2015;41:125\u2013131.<\/jats:bold> \u00a9 <jats:bold>2013 Wiley Periodicals, Inc<\/jats:bold>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.24508","type":"journal-article","created":{"date-parts":[[2013,11,24]],"date-time":"2013-11-24T16:38:18Z","timestamp":1385311098000},"page":"125-131","source":"Crossref","is-referenced-by-count":15,"title":["DWI findings of autoimmune pancreatitis: Comparison between symptomatic and asymptomatic patients"],"prefix":"10.1002","volume":"41","author":[{"given":"Hodaka","family":"Oki","sequence":"first","affiliation":[{"name":"Department of Radiology University of Occupational and Environmental Health, Yahatanishi\u2010ku Kitakyushu Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiko","family":"Hayashida","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Occupational and Environmental Health, Yahatanishi\u2010ku Kitakyushu Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruka","family":"Oki","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Occupational and Environmental Health, Yahatanishi\u2010ku Kitakyushu Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shingo","family":"Kakeda","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Occupational and Environmental Health, Yahatanishi\u2010ku Kitakyushu Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takatoshi","family":"Aoki","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Occupational and Environmental Health, Yahatanishi\u2010ku Kitakyushu Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masashi","family":"Taguchi","sequence":"additional","affiliation":[{"name":"Third Department of Internal Medicine University of Occupational and Environmental Health, Yahatanishiku Kitakyushu Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaru","family":"Harada","sequence":"additional","affiliation":[{"name":"Third Department of Internal Medicine University of Occupational and Environmental Health, Yahatanishiku Kitakyushu Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukunori","family":"Korogi","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Occupational and Environmental Health, Yahatanishi\u2010ku Kitakyushu Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,11,22]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPA.0b013e3181bba281"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0903068"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2009.327"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5107(04)00344-X"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPA.0b013e3181b9ee1c"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006676-200307000-00002"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-007-2048-6"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-004-1140-z"},{"key":"e_1_2_5_10_1","first-page":"471","article-title":"Japanese consensus guidelines for management of autoimmune pancreatitis III","volume":"45","author":"Kamisawa T","year":"2010","journal-title":"Treatment and prognosis of AIP. J Gastroenterol"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11547-009-0452-0"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.170.5.9574610"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s003300000742"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v12.i18.2919"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.11101729"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2423060003"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11604-008-0311-2"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-008-2205-6"},{"key":"e_1_2_5_19_1","first-page":"249","article-title":"Japanese consensus guidelines for management of autoimmune pancreatitis","volume":"45","author":"Okazaki K","year":"2010","journal-title":"I. Concept and diagnosis of autoimmune pancreatitis. J Gastroenterol"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2332031436"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00261-005-0047-8"},{"key":"e_1_2_5_22_1","first-page":"76","article-title":"Biliary tract involvement in autoimmune pancreatitis","volume":"30","author":"Nishino T","year":"2005","journal-title":"Pancreas"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.2307\/2529310"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1699-0463.1989.tb00464.x"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(1950)3:1<32::AID-CNCR2820030106>3.0.CO;2-3"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2472070598"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1159\/000055819"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2493080279"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2010.87"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2006.05.017"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-007-2047-7"}],"container-title":["Journal of Magnetic Resonance Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjmri.24508","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmri.24508","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T11:19:42Z","timestamp":1696331982000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmri.24508"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11,22]]},"references-count":30,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,1]]}},"alternative-id":["10.1002\/jmri.24508"],"URL":"https:\/\/doi.org\/10.1002\/jmri.24508","archive":["Portico"],"relation":{},"ISSN":["1053-1807","1522-2586"],"issn-type":[{"value":"1053-1807","type":"print"},{"value":"1522-2586","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,11,22]]}}}