{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T05:28:21Z","timestamp":1791178101244,"version":"4.1.0"},"reference-count":47,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,11,22]],"date-time":"2013-11-22T00:00:00Z","timestamp":1385078400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p>To evaluate the utility of two\u2010dimensional (2D) Localized Correlated Spectroscopy (L\u2010COSY) in metabolic profiling of the human brain at 7 Tesla (T).<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>The 2D L\u2010COSY sequence was implemented at 7T and its reliability was assessed by test\u2013retest studies of a metabolite phantom and a healthy volunteer. L\u2010COSY data were acquired from the occipital lobe of healthy subjects (n\u2009=\u20096; all male; age, 30\u201372 years) to assess intersubject variability. Additionally, two subjects underwent scans from the parieto\u2010occipital region, basal ganglia, frontal lobe or dorsolateral prefrontal cortex to test the versatility of L\u2010COSY in studying differing anatomy. Integral\/volume measurements of L\u2010COSY spectra were used to estimate normalized metabolite\u2010to\u2010creatine concentrations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Phantom test\u2013retest studies revealed coefficients of variation (CVs) of 3\u201320% for most metabolites. Human 2D L\u2010COSY spectra permitted detection of several metabolite resonances from multiple locations and inter\u2010subject variation studies demonstrated CVs of 4\u201326%. Cross\u2010peaks from gamma\u2010aminobutyric acid (GABA), isoleucine (Ile), lysine (Lys) and Ethanolamine (Eth) were quantified, which are not readily resolvable with conventional one\u2010dimensional (1D) MR spectroscopy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>2D L\u2010COSY at 7T demonstrated improved sensitivity in detecting additional metabolites with reliability comparable to established techniques at lower fields, which may aid in the metabolic assessment of diseased states. <jats:bold>J. Magn. Reson. Imaging 2014;40:1319\u20131327<\/jats:bold>. \u00a9 <jats:bold>2013 Wiley Periodicals, Inc<\/jats:bold>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.24510","type":"journal-article","created":{"date-parts":[[2013,11,24]],"date-time":"2013-11-24T16:18:34Z","timestamp":1385309914000},"page":"1319-1327","source":"Crossref","is-referenced-by-count":15,"title":["Implementation of two\u2010dimensional L\u2010COSY at 7 tesla: An investigation of reproducibility in human brain"],"prefix":"10.1002","volume":"40","author":[{"given":"Gaurav","family":"Verma","sequence":"first","affiliation":[{"name":"Department of Radiology University of Pennsylvania Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hari","family":"Hariharan","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Pennsylvania Philadelphia Pennsylvania 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