{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T07:52:43Z","timestamp":1778658763446,"version":"3.51.4"},"reference-count":32,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,1,6]],"date-time":"2014-01-06T00:00:00Z","timestamp":1388966400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p>To determine the relation between glucose metabolic changes of the primary visual cortex, structural abnormalities of the corresponding visual tracts, and visual symptoms in children with Sturge\u2010Weber syndrome (SWS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>In 10 children with unilateral SWS (ages 1.5\u20135.5 years), a region\u2010of\u2010interest analysis was applied in the bilateral medial occipital cortex on positron emission tomography (PET) and used to track diffusion\u2010weighted imaging (DWI) streamlines corresponding to the central visual pathway. Normalized streamline volumes of individual SWS patients were compared with values from age\u2010matched control groups as well as correlated with normalized glucose uptakes and visual field deficit.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Lower glucose uptake and lower corresponding streamline volumes were detected in the affected occipital lobe in 9\/10 patients, as compared to the contralateral side. Seven of these 9 patients had visual field deficit and normal or decreased streamline volumes on the unaffected side. The two other children had no visual symptoms and showed high contralateral visual streamline volumes. There was a positive correlation between the normalized ratios on DWI and PET, indicating that lower glucose metabolism was associated with lower streamline volume in the affected hemisphere (R\u2009=\u20090.70, <jats:italic>P<\/jats:italic>\u2009=\u20090.024).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We demonstrated that 18F\u2010flurodeoxyglucose (FDG)\u2010PET combined with DWI tractography can detect both brain damage on the side of the lesion and contralateral plasticity in children with early occipital lesions.<jats:bold>J. Magn. Reson. Imaging 2014;00:000\u2013000.<\/jats:bold> \u00a9 <jats:bold>2014 Wiley Periodicals, Inc.<\/jats:bold> <jats:bold>J. Magn. Reson. Imaging 2015;41:431\u2013438.<\/jats:bold>\u00a9 <jats:bold>2013 Wiley Periodicals, Inc<\/jats:bold>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.24556","type":"journal-article","created":{"date-parts":[[2014,1,6]],"date-time":"2014-01-06T06:38:39Z","timestamp":1388990319000},"page":"431-438","source":"Crossref","is-referenced-by-count":10,"title":["Assessment of brain damage and plasticity in the visual system due to early occipital lesion: Comparison of FDG\u2010PET with diffusion MRI tractography"],"prefix":"10.1002","volume":"41","author":[{"given":"Jeong\u2010won","family":"Jeong","sequence":"first","affiliation":[{"name":"Department of Pediatrics, School of Medicine Wayne State University Detroit Michigan USA"},{"name":"Department of Neurology, School of Medicine Wayne State University Detroit Michigan USA"},{"name":"PET Center and Translational Imaging Laboratory Children's Hospital of Michigan Detroit Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vijay N.","family":"Tiwari","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, School of Medicine Wayne State University Detroit Michigan USA"},{"name":"Department of Neurology, School of Medicine Wayne State University Detroit Michigan USA"},{"name":"PET Center and Translational Imaging Laboratory Children's Hospital of Michigan Detroit Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph","family":"Shin","sequence":"additional","affiliation":[{"name":"PET Center and Translational Imaging Laboratory Children's Hospital of Michigan Detroit Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harry T.","family":"Chugani","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, School of Medicine Wayne State University Detroit Michigan USA"},{"name":"Department of Neurology, School of Medicine Wayne State University Detroit Michigan USA"},{"name":"PET Center and Translational Imaging Laboratory Children's Hospital of Michigan Detroit Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Csaba","family":"Juh\u00e1sz","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, School of Medicine Wayne State University Detroit Michigan USA"},{"name":"Department of Neurology, School of Medicine Wayne State University Detroit Michigan USA"},{"name":"PET Center and Translational Imaging Laboratory Children's Hospital of Michigan Detroit Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,1,6]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1213507"},{"key":"e_1_2_6_3_1","first-page":"19","volume-title":"Sturge\u2010Weber syndrome","author":"Bodensteiner JB","year":"2010"},{"key":"e_1_2_6_4_1","first-page":"69","volume-title":"Sturge\u2010Weber 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